Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152330" target="_blank" >RIV/00216305:26620/24:PU152330 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081723:_____/24:00599161 RIV/00216224:14110/24:00136681 RIV/65269705:_____/24:00080312 RIV/00159816:_____/24:00080312

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0272884224033790?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0272884224033790?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ceramint.2024.07.433" target="_blank" >10.1016/j.ceramint.2024.07.433</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method

Popis výsledku v původním jazyce

The effect of silica (SiO2) addition (0 wt%-20 wt%) on the microstructural and mechanical properties, as well as the in vitro response of calcium phosphate scaffolds for potential application in bone tissue engineering (BTE) was investigated in this research. Scaffolds characterized by high porosity (77%-88 %) and interconnected spherical pores with a broad range of pore sizes (5-600 mu m) were fabricated using in-situ foaming method. Incorporated silica affected the phase transformation of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) and led to the development of new crystalline silica-rich phases like silicocarnotite and wollastonite. The reinforcement of silica became apparent during the tests of mechanical properties. Scaffolds with 5 wt% of SiO2 exhibited compressive strength (1.13 MPa) higher than pure HA scaffolds (0.93 MPa). Bone bonding potential of the materials was tested in simulated body fluid (SBF), demonstrating this potential in silica-doped samples. Additionally, degradation experiments showed gradual material degradation, making it suitable for BTE applications. Furthermore, cell culture studies using human mesenchymal stromal cells (MSC) confirmed the scaffold's non- toxicity and provided insights into how the silica content influences cell viability, morphology, and osteogenic potential. The findings of this study offer valuable insights into the design and development of advanced scaffolds with tailored properties for effective BTE applications.

Název v anglickém jazyce

Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method

Popis výsledku anglicky

The effect of silica (SiO2) addition (0 wt%-20 wt%) on the microstructural and mechanical properties, as well as the in vitro response of calcium phosphate scaffolds for potential application in bone tissue engineering (BTE) was investigated in this research. Scaffolds characterized by high porosity (77%-88 %) and interconnected spherical pores with a broad range of pore sizes (5-600 mu m) were fabricated using in-situ foaming method. Incorporated silica affected the phase transformation of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) and led to the development of new crystalline silica-rich phases like silicocarnotite and wollastonite. The reinforcement of silica became apparent during the tests of mechanical properties. Scaffolds with 5 wt% of SiO2 exhibited compressive strength (1.13 MPa) higher than pure HA scaffolds (0.93 MPa). Bone bonding potential of the materials was tested in simulated body fluid (SBF), demonstrating this potential in silica-doped samples. Additionally, degradation experiments showed gradual material degradation, making it suitable for BTE applications. Furthermore, cell culture studies using human mesenchymal stromal cells (MSC) confirmed the scaffold's non- toxicity and provided insights into how the silica content influences cell viability, morphology, and osteogenic potential. The findings of this study offer valuable insights into the design and development of advanced scaffolds with tailored properties for effective BTE applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20504 - Ceramics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CERAMICS INTERNATIONAL

ISSN

0272-8842

e-ISSN

1873-3956

Svazek periodika

50

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

41215-41227

Kód UT WoS článku

001327513100001

EID výsledku v databázi Scopus

2-s2.0-85200225907