Scaffold microstructure evolution via freeze-casting and hydrothermal phase transformation of calcium phosphate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU155966" target="_blank" >RIV/00216305:26620/24:PU155966 - isvavai.cz</a>

Výsledek na webu

<a href="https://ceramics.onlinelibrary.wiley.com/doi/10.1111/jace.20053" target="_blank" >https://ceramics.onlinelibrary.wiley.com/doi/10.1111/jace.20053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jace.20053" target="_blank" >10.1111/jace.20053</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Scaffold microstructure evolution via freeze-casting and hydrothermal phase transformation of calcium phosphate

Popis výsledku v původním jazyce

Extensive research efforts have been focused on customizing the microstructure, macrostructure, and phase composition of calcium phosphate for enhanced biocompatibility and bioactivity in scaffolds for bone substitutes. Despite significant progress, achieving precise phase composition and microstructure remains a challenge, primarily due to the necessity of scaffold sintering. This study addresses the challenges in developing customized patient-specific bone substitutes by proposing a sequential approach that reduces processing steps while providing control over the phase and morphology of the scaffolds' structure. The methodology utilizes freeze-casting and sintering for highly porous the scaffolds' preparation, followed by hydrothermal treatment to modify the microstructure. The introduction of CaCO3 induces a phase transformation of tricalcium phosphate, increasing the hydroxyapatite content, while the overall macrostructure retains the characteristics of freeze-casting. The surface morphology undergoes a transition from equiaxial grains to whiskers-like structures and hexagonal rods, impacting compressive strength. Following hydrothermal treatment, the formation of whiskers-like hydroxyapatite grains leads to a notable strength increase from 2.8 to 5.7 MPa. Remarkably, the scaffolds undergo nearly complete phase transformation, shifting from 100% tricalcium phosphate to 99% hydroxyapatite, all while conserving the macrostructure. Scaffolds with enhanced porosity and altered surface morphologies were created through freeze-casting, sintering, and subsequent hydrothermal treatment. The modified scaffolds maintained their overall macrostructure, displaying high porosity (>= 60%), diverse hydroxyapatite phase ratios (0-99%), and a compressive strength of 5.7 MPa. This study introduces a novel approach employing hydrothermal treatment for microstructural and phase customization of sintered scaffolds. image

Název v anglickém jazyce

Scaffold microstructure evolution via freeze-casting and hydrothermal phase transformation of calcium phosphate

Popis výsledku anglicky

Extensive research efforts have been focused on customizing the microstructure, macrostructure, and phase composition of calcium phosphate for enhanced biocompatibility and bioactivity in scaffolds for bone substitutes. Despite significant progress, achieving precise phase composition and microstructure remains a challenge, primarily due to the necessity of scaffold sintering. This study addresses the challenges in developing customized patient-specific bone substitutes by proposing a sequential approach that reduces processing steps while providing control over the phase and morphology of the scaffolds' structure. The methodology utilizes freeze-casting and sintering for highly porous the scaffolds' preparation, followed by hydrothermal treatment to modify the microstructure. The introduction of CaCO3 induces a phase transformation of tricalcium phosphate, increasing the hydroxyapatite content, while the overall macrostructure retains the characteristics of freeze-casting. The surface morphology undergoes a transition from equiaxial grains to whiskers-like structures and hexagonal rods, impacting compressive strength. Following hydrothermal treatment, the formation of whiskers-like hydroxyapatite grains leads to a notable strength increase from 2.8 to 5.7 MPa. Remarkably, the scaffolds undergo nearly complete phase transformation, shifting from 100% tricalcium phosphate to 99% hydroxyapatite, all while conserving the macrostructure. Scaffolds with enhanced porosity and altered surface morphologies were created through freeze-casting, sintering, and subsequent hydrothermal treatment. The modified scaffolds maintained their overall macrostructure, displaying high porosity (>= 60%), diverse hydroxyapatite phase ratios (0-99%), and a compressive strength of 5.7 MPa. This study introduces a novel approach employing hydrothermal treatment for microstructural and phase customization of sintered scaffolds. image

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20504 - Ceramics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF THE AMERICAN CERAMIC SOCIETY

ISSN

0002-7820

e-ISSN

1551-2916

Svazek periodika

107

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

7994-8006

Kód UT WoS článku

001285647400001

EID výsledku v databázi Scopus

2-s2.0-85200509561