Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0197800" target="_blank" >RIV/00216305:26620/26:0197800 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11837-025-07353-8" target="_blank" >https://link.springer.com/article/10.1007/s11837-025-07353-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11837-025-07353-8" target="_blank" >10.1007/s11837-025-07353-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Popis výsledku v původním jazyce

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

Název v anglickém jazyce

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Popis výsledku anglicky

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20500 - Materials engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOM

ISSN

1047-4838

e-ISSN

1543-1851

Svazek periodika

77

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

4473-4492

Kód UT WoS článku

001470066000001

EID výsledku v databázi Scopus

2-s2.0-105003409557