Nanorobot-Cell Communication via <i>In Situ</i> Generation of Biochemical Signals: Toward Regenerative Therapies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0198687" target="_blank" >RIV/00216305:26620/26:0198687 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsnano.5c02092" target="_blank" >https://pubs.acs.org/doi/10.1021/acsnano.5c02092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsnano.5c02092" target="_blank" >10.1021/acsnano.5c02092</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanorobot-Cell Communication via <i>In Situ</i> Generation of Biochemical Signals: Toward Regenerative Therapies

Popis výsledku v původním jazyce

Achieving precise control of cellular processes drives possibilities for next-generation therapeutic approaches. However, existing technologies for influencing cell behavior primarily rely on specific drug delivery, limiting their ability to mimic natural cellular communication processes. In this work, we developed glucose-powered gold-silica (Au-SiO2) nanorobots that induce cell migration by generating steady-state hydrogen peroxide (H2O2) as a biochemical signaling molecule to mimic natural cellular communication with high spatial resolution. These nanorobots leverage the unique 2-in-1 catalytic activity of gold nanoparticles for glucose oxidation and H2O2 decomposition, allowing for precise control over the generation of steady-state H2O2 concentration and enhanced diffusion powered by glucose within the cellular microenvironment. We further demonstrated that at low dosages of nanorobots, the steady-state H2O2 generation promotes cell migration and proliferation, while higher dosages of nanorobots slow down cell proliferation. The proposed design of this biocompatible nanorobot is intended to enable communication with the environment and provide a noninvasive, biochemical command system for regulating cellular behavior. Additionally, we show proof of principle of a method by which nanorobots can augment wound healing and similar regenerative therapies.

Název v anglickém jazyce

Nanorobot-Cell Communication via <i>In Situ</i> Generation of Biochemical Signals: Toward Regenerative Therapies

Popis výsledku anglicky

Achieving precise control of cellular processes drives possibilities for next-generation therapeutic approaches. However, existing technologies for influencing cell behavior primarily rely on specific drug delivery, limiting their ability to mimic natural cellular communication processes. In this work, we developed glucose-powered gold-silica (Au-SiO2) nanorobots that induce cell migration by generating steady-state hydrogen peroxide (H2O2) as a biochemical signaling molecule to mimic natural cellular communication with high spatial resolution. These nanorobots leverage the unique 2-in-1 catalytic activity of gold nanoparticles for glucose oxidation and H2O2 decomposition, allowing for precise control over the generation of steady-state H2O2 concentration and enhanced diffusion powered by glucose within the cellular microenvironment. We further demonstrated that at low dosages of nanorobots, the steady-state H2O2 generation promotes cell migration and proliferation, while higher dosages of nanorobots slow down cell proliferation. The proposed design of this biocompatible nanorobot is intended to enable communication with the environment and provide a noninvasive, biochemical command system for regulating cellular behavior. Additionally, we show proof of principle of a method by which nanorobots can augment wound healing and similar regenerative therapies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/LM2023050" target="_blank" >LM2023050: Národní infrastruktura pro biologické a medicínské zobrazování</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Nano

ISSN

1936-0851

e-ISSN

1936-086X

Svazek periodika

19

Číslo periodika v rámci svazku

25

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

22953-22967

Kód UT WoS článku

001514177100001

EID výsledku v databázi Scopus

2-s2.0-105008311484