Low-temperature sintered boron-doped S53P4 bioactive glass scaffolds fabricated by robocasting

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0199461" target="_blank" >RIV/00216305:26620/26:0199461 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1111/jace.70292" target="_blank" >https://doi.org/10.1111/jace.70292</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jace.70292" target="_blank" >10.1111/jace.70292</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low-temperature sintered boron-doped S53P4 bioactive glass scaffolds fabricated by robocasting

Popis výsledku v původním jazyce

This study investigates boron-doped S53P4 bioactive glass (BG) scaffolds fabricated via robocasting in the context of bone regeneration strategies by comparing their mechanical performance and bioactive behavior to undoped S53P4 BG scaffolds. Three-dimensional scaffolds with grid-like macro architectures were fabricated using gelatin-based composite inks containing S53P4 BG and 10 wt.% boron-doped S53P4 BG (S53P4_10B). The scaffolds were sintered at optimized temperatures (900 degrees C for S53P4 and 615 degrees C for S53P4_10B), resulting in an average volumetric shrinkage of 33 vol%. Both scaffold types exhibited high porosity (similar to 71%) with pore sizes of 584 +/- 7 mu m (S53P4) and 608 +/- 25 mu m (S53P4_10B). Compressive strength values of 3.3 +/- 1.7 MPa and 1.5 +/- 0.4 MPa were respectively measured for S53P4 and for S53P4_10B BG scaffolds. Soaking in simulated body fluid for 14 days resulted in complete surface coverage with calcium-phosphate-rich phases, indicating high bioactivity. Antibacterial tests revealed that while crystallization reduced the inhibition zone of S53P4 scaffolds, S53P4_10B scaffolds exhibited significant antibacterial activity against E. coli and S. aureus. Cytocompatibility tests using MG-63 and ST-2 cell lines confirmed that scaffold extracts at concentrations

Název v anglickém jazyce

Low-temperature sintered boron-doped S53P4 bioactive glass scaffolds fabricated by robocasting

Popis výsledku anglicky

This study investigates boron-doped S53P4 bioactive glass (BG) scaffolds fabricated via robocasting in the context of bone regeneration strategies by comparing their mechanical performance and bioactive behavior to undoped S53P4 BG scaffolds. Three-dimensional scaffolds with grid-like macro architectures were fabricated using gelatin-based composite inks containing S53P4 BG and 10 wt.% boron-doped S53P4 BG (S53P4_10B). The scaffolds were sintered at optimized temperatures (900 degrees C for S53P4 and 615 degrees C for S53P4_10B), resulting in an average volumetric shrinkage of 33 vol%. Both scaffold types exhibited high porosity (similar to 71%) with pore sizes of 584 +/- 7 mu m (S53P4) and 608 +/- 25 mu m (S53P4_10B). Compressive strength values of 3.3 +/- 1.7 MPa and 1.5 +/- 0.4 MPa were respectively measured for S53P4 and for S53P4_10B BG scaffolds. Soaking in simulated body fluid for 14 days resulted in complete surface coverage with calcium-phosphate-rich phases, indicating high bioactivity. Antibacterial tests revealed that while crystallization reduced the inhibition zone of S53P4 scaffolds, S53P4_10B scaffolds exhibited significant antibacterial activity against E. coli and S. aureus. Cytocompatibility tests using MG-63 and ST-2 cell lines confirmed that scaffold extracts at concentrations

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

20504 - Ceramics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American Ceramic Society

ISSN

0002-7820

e-ISSN

1551-2916

Svazek periodika

1

Číslo periodika v rámci svazku

109

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

1-20

Kód UT WoS článku

001589426700001

EID výsledku v databázi Scopus

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