Continuous electrochemical H2O2 delivery for cancer cell treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0200771" target="_blank" >RIV/00216305:26620/26:0200771 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2026/tb/d5tb01244a" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2026/tb/d5tb01244a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5tb01244a" target="_blank" >10.1039/d5tb01244a</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Continuous electrochemical H2O2 delivery for cancer cell treatment

Popis výsledku v původním jazyce

Hydrogen peroxide (H2O2) has emerged as a promising agent in cancer therapy due to its ability to induce oxidative stress selectively in tumor cells, however, its efficacy is severely hampered by H2O2 breakdown when administered via standard routes. Our study introduces an innovative electrochemical method for the controlled and continuous delivery of H2O2 directly to cancer cells, potentially enhancing the efficacy of cancer treatments. We investigated the performance of gold, titanium, stainless steel, and poly(3,4-ethylenedioxythiophene), PEDOT, electrodes in generating H2O2, with PEDOT exhibiting superior consistency and efficiency in cell culture medium. The galvanostatic delivery of H2O2 demonstrated a dose-dependent reduction in cell viability for U87 glioblastoma and A375 melanoma cells, confirming the cytotoxic impact of H2O2. The addition of catalase restored cell viability, further validating the specificity of H2O2-induced cell death. Our results showed that U87 cells exhibited higher resistance to H2O2 compared to A375 cells, aligning with known tumor-specific variations in H2O2 metabolism. This novel approach of electrochemical H2O2 delivery holds significant potential for enhancing targeted cancer therapies, offering a controllable, precise, and efficient method for inducing tumor cell death while minimizing damage to healthy tissues. These results showcase the remarkable ability of PEDOT electrodes as a reliable electrocatalytic source of on-demand H2O2 in electrochemically-challenging biological environments.

Název v anglickém jazyce

Continuous electrochemical H2O2 delivery for cancer cell treatment

Popis výsledku anglicky

Hydrogen peroxide (H2O2) has emerged as a promising agent in cancer therapy due to its ability to induce oxidative stress selectively in tumor cells, however, its efficacy is severely hampered by H2O2 breakdown when administered via standard routes. Our study introduces an innovative electrochemical method for the controlled and continuous delivery of H2O2 directly to cancer cells, potentially enhancing the efficacy of cancer treatments. We investigated the performance of gold, titanium, stainless steel, and poly(3,4-ethylenedioxythiophene), PEDOT, electrodes in generating H2O2, with PEDOT exhibiting superior consistency and efficiency in cell culture medium. The galvanostatic delivery of H2O2 demonstrated a dose-dependent reduction in cell viability for U87 glioblastoma and A375 melanoma cells, confirming the cytotoxic impact of H2O2. The addition of catalase restored cell viability, further validating the specificity of H2O2-induced cell death. Our results showed that U87 cells exhibited higher resistance to H2O2 compared to A375 cells, aligning with known tumor-specific variations in H2O2 metabolism. This novel approach of electrochemical H2O2 delivery holds significant potential for enhancing targeted cancer therapies, offering a controllable, precise, and efficient method for inducing tumor cell death while minimizing damage to healthy tissues. These results showcase the remarkable ability of PEDOT electrodes as a reliable electrocatalytic source of on-demand H2O2 in electrochemically-challenging biological environments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

2050-7518

Svazek periodika

14

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

894-902

Kód UT WoS článku

001639477000001

EID výsledku v databázi Scopus

2-s2.0-105024858548