Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F13%3A10209983" target="_blank" >RIV/00669806:_____/13:10209983 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628888/pdf/medscimonit-19-81.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628888/pdf/medscimonit-19-81.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.883755" target="_blank" >10.12659/MSM.883755</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study

Popis výsledku v původním jazyce

Background: Citrulline is an amino acid produced by enterocytes. Serum citrulline concentration has been proposed as a marker of enterocyte mass and function. Our study focused on evaluation of citrulline levels in patients with diarrhea related to toxicintestinal damage (mucositis), intestinal graft versus host disease (GVHD), and other etiology of diarrhea (e. g., dysmicrobia) after allogeneic stem cells transplantation (SCT). Material/Methods: This was a prospective study in 11 adults (18 blood samples) with diarrhea developed after allogeneic SCT in 4/2011-1/2012 compared to twenty healthy control samples. Results: The median (interquartile range) of citrulline levels was significantly lower in the transplanted patients group compared to healthy controls: 9.3 (3.62-15.38) vs. 33.3 (26.82-36.23) mu mol/L, p<0.0001. The median values of citrulline in patients with post-transplant toxic intestinal mucositis (n=8, days 1-22 post-transplant) vs. intestinal GVHD (n=7, day 43-142) vs. ot

Název v anglickém jazyce

Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study

Popis výsledku anglicky

Background: Citrulline is an amino acid produced by enterocytes. Serum citrulline concentration has been proposed as a marker of enterocyte mass and function. Our study focused on evaluation of citrulline levels in patients with diarrhea related to toxicintestinal damage (mucositis), intestinal graft versus host disease (GVHD), and other etiology of diarrhea (e. g., dysmicrobia) after allogeneic stem cells transplantation (SCT). Material/Methods: This was a prospective study in 11 adults (18 blood samples) with diarrhea developed after allogeneic SCT in 4/2011-1/2012 compared to twenty healthy control samples. Results: The median (interquartile range) of citrulline levels was significantly lower in the transplanted patients group compared to healthy controls: 9.3 (3.62-15.38) vs. 33.3 (26.82-36.23) mu mol/L, p<0.0001. The median values of citrulline in patients with post-transplant toxic intestinal mucositis (n=8, days 1-22 post-transplant) vs. intestinal GVHD (n=7, day 43-142) vs. ot

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Science Monitor [online]

ISSN

1643-3750

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

5

Strana od-do

81-85

Kód UT WoS článku

000319920000001

EID výsledku v databázi Scopus

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