Utility of laboratory testing for the diagnosis of Hymenoptera venom allergy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F16%3A10323936" target="_blank" >RIV/00669806:_____/16:10323936 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10323936

Výsledek na webu

<a href="http://dx.doi.org/10.2500/aap.2016.37.3934" target="_blank" >http://dx.doi.org/10.2500/aap.2016.37.3934</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2500/aap.2016.37.3934" target="_blank" >10.2500/aap.2016.37.3934</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Utility of laboratory testing for the diagnosis of Hymenoptera venom allergy

Popis výsledku v původním jazyce

Background: A diagnosis of Hymenoptera venom allergy is based on clinical history and the results of skin tests and/or laboratory methods. Objective: To analyze the utility of available laboratory tests in diagnosing Hymenoptera venom allergy. Methods: Ninety-five patients with Hymenoptera venom allergy with a history of bee (35) or wasp (60) anaphylactic sting reaction and positive skin test with bee or wasp venom were included in this analysis. Specific immunoglobulin E (to bee venom extract, wasp venom extract, available recombinant molecules, and a basophil activation test with venom extracts were assessed in all the patients. Test sensitivity and specificity were calculated by using standard threshold values; then, receiver operating characteristic curve analysis was performed to compute optimal threshold values. Also, statistical analysis of the utility of different combinations of laboratory tests was performed. Conclusion: Our analysis confirmed that currently used laboratory tests represent effective tools in diagnosing Hymenoptera venom allergy. Moreover, our probabilistic approach offered another way to interpret concrete values of laboratory test results and opened possible direction on how to optimize the laboratory diagnostic procedure.

Název v anglickém jazyce

Utility of laboratory testing for the diagnosis of Hymenoptera venom allergy

Popis výsledku anglicky

Background: A diagnosis of Hymenoptera venom allergy is based on clinical history and the results of skin tests and/or laboratory methods. Objective: To analyze the utility of available laboratory tests in diagnosing Hymenoptera venom allergy. Methods: Ninety-five patients with Hymenoptera venom allergy with a history of bee (35) or wasp (60) anaphylactic sting reaction and positive skin test with bee or wasp venom were included in this analysis. Specific immunoglobulin E (to bee venom extract, wasp venom extract, available recombinant molecules, and a basophil activation test with venom extracts were assessed in all the patients. Test sensitivity and specificity were calculated by using standard threshold values; then, receiver operating characteristic curve analysis was performed to compute optimal threshold values. Also, statistical analysis of the utility of different combinations of laboratory tests was performed. Conclusion: Our analysis confirmed that currently used laboratory tests represent effective tools in diagnosing Hymenoptera venom allergy. Moreover, our probabilistic approach offered another way to interpret concrete values of laboratory test results and opened possible direction on how to optimize the laboratory diagnostic procedure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Allergy and Asthma Proceedings

ISSN

1088-5412

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

248-255

Kód UT WoS článku

000375718500012

EID výsledku v databázi Scopus

2-s2.0-84968690756