Allogeneic Stem Cell Transplantation in Patients With FLT3-ITD Mutated AML: Transplantation in CR1 Is the Decisive Factor for Good Outcome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F19%3A10396562" target="_blank" >RIV/00669806:_____/19:10396562 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/19:10396562 RIV/00098892:_____/19:N0000045

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pk1wj3IaBI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pk1wj3IaBI</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clml.2019.04.005" target="_blank" >10.1016/j.clml.2019.04.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Allogeneic Stem Cell Transplantation in Patients With FLT3-ITD Mutated AML: Transplantation in CR1 Is the Decisive Factor for Good Outcome

Popis výsledku v původním jazyce

Patients with internal tandem duplication in fms-related tyrosine kinase receptor gene 3 acute myeloid leukemia have a poor outcome and early allogeneic stem cell transplantation (alloSCT) seems to be the only curative modality. Our data confirm that early alloSCT remains the best consolidation therapy (even for older patients) and should be performed immediately in first complete remission (CR1). The unsatisfactory results with alloSCT beyond CR1 disqualify the policy of postponement stem cell transplantation until relapse and suggest that innovative approaches are needed for such patients. Background: Patients with internal tandem duplication in fms-related tyrosine kinase receptor gene 3 (FLT3-ITD)-mutated acute myeloid leukemia (AML) have a dismal prognosis and the only curative option seems to be allogeneic stem cell transplantation (alloSCT). However, its timing is still matter of debate. Patients and Methods: We retrospectively analyzed 73 consecutive AML patients with FLT3-ITD (median age 53, range 20-68 years) allografted with consistent policy to try to refer them all for upfront alloSCT in first complete remission (CR1). Results: With a median follow-up of 44 (range, 5-135) months the 5-year overall survival (OS)/disease-free survival (DFS) probabilities were 49%/47%. The cumulative incidence of relapse and nonrelapse mortality (NRM) were 37% and 14%, respectively. The estimated 5-year OS for patients who received transplantation in CR1 was 62% versus 0% for patients who received trans-plantation beyond CR1. Multivariable analysis identified stem cell transplantation beyond CR1 as the key factor for poor OS (hazard ratio [HR], 5.41; P &lt; .0001), DFS (HR, 4.41; P = .0002), and high relapse incidence (HR, 8.08; P &lt; .0001). Acute graft versus host disease Grade &gt;= 3 predicted higher NRM (HR, 3.80; P = .059) as well as inferior OS (HR, 2.04; P = .0079). No association of patient age, nucleophosmin status, donor type, conditioning, and other variables on the survival was detected. Conclusion: AlloSCT should be regarded with urgency as soon as CR1 is achieved in this subset of AML patients.

Název v anglickém jazyce

Allogeneic Stem Cell Transplantation in Patients With FLT3-ITD Mutated AML: Transplantation in CR1 Is the Decisive Factor for Good Outcome

Popis výsledku anglicky

Patients with internal tandem duplication in fms-related tyrosine kinase receptor gene 3 acute myeloid leukemia have a poor outcome and early allogeneic stem cell transplantation (alloSCT) seems to be the only curative modality. Our data confirm that early alloSCT remains the best consolidation therapy (even for older patients) and should be performed immediately in first complete remission (CR1). The unsatisfactory results with alloSCT beyond CR1 disqualify the policy of postponement stem cell transplantation until relapse and suggest that innovative approaches are needed for such patients. Background: Patients with internal tandem duplication in fms-related tyrosine kinase receptor gene 3 (FLT3-ITD)-mutated acute myeloid leukemia (AML) have a dismal prognosis and the only curative option seems to be allogeneic stem cell transplantation (alloSCT). However, its timing is still matter of debate. Patients and Methods: We retrospectively analyzed 73 consecutive AML patients with FLT3-ITD (median age 53, range 20-68 years) allografted with consistent policy to try to refer them all for upfront alloSCT in first complete remission (CR1). Results: With a median follow-up of 44 (range, 5-135) months the 5-year overall survival (OS)/disease-free survival (DFS) probabilities were 49%/47%. The cumulative incidence of relapse and nonrelapse mortality (NRM) were 37% and 14%, respectively. The estimated 5-year OS for patients who received transplantation in CR1 was 62% versus 0% for patients who received trans-plantation beyond CR1. Multivariable analysis identified stem cell transplantation beyond CR1 as the key factor for poor OS (hazard ratio [HR], 5.41; P &lt; .0001), DFS (HR, 4.41; P = .0002), and high relapse incidence (HR, 8.08; P &lt; .0001). Acute graft versus host disease Grade &gt;= 3 predicted higher NRM (HR, 3.80; P = .059) as well as inferior OS (HR, 2.04; P = .0079). No association of patient age, nucleophosmin status, donor type, conditioning, and other variables on the survival was detected. Conclusion: AlloSCT should be regarded with urgency as soon as CR1 is achieved in this subset of AML patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Lymphoma, Myeloma &amp; Leukemia

ISSN

2152-2650

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

462-469

Kód UT WoS článku

000477732800022

EID výsledku v databázi Scopus

2-s2.0-85065774893