Blunt injury of liver - mechanical response of porcine liver in experimental impact test

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F21%3A10422774" target="_blank" >RIV/00669806:_____/21:10422774 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/21:10422774 RIV/49777513:23520/21:43961014 RIV/49777513:23640/21:43961014

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NtQVQ~fhuo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NtQVQ~fhuo</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1361-6579/abdf3c" target="_blank" >10.1088/1361-6579/abdf3c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Blunt injury of liver - mechanical response of porcine liver in experimental impact test

Popis výsledku v původním jazyce

Liver is frequently injured in blunt abdominal trauma caused by road traffic accidents. The testing of safety performance of vehicles, e.g. belt usage, head support, seat shape, or air bag shape, material, pressure, and reaction, could lead to reduction of the injury seriousness. Current trends in safety testing include development of accurate computational human body models (HBM&apos;s) based on the anatomical, morphological, and mechanical behavior of tissues under high strain. The aim of this study was to describe the internal pressure changes within porcine liver, the severity of liver injury and the relation between the porcine liver microstructure and rupture propagation in an experimental impact test. Porcine liver specimens (n = 24) were uniformly compressed using a drop tower technique and four impact heights (200, 300, 400 and 500 mm; corresponding velocities: 1.72, 2.17, 2.54, and 2.88 m/s). The changes in intravascular pressure were measured via catheters placed in portal vein and caudate vena cava. The induced injuries were analyzed on macroscopic level according to AAST grade and AIS severity. Rupture propagation with respect to liver microstructure was analyzed using stereological methods. Macroscopic ruptures affected mostly the interface between connective tissue surrounding big vessels and liver parenchyma. Histological analysis revealed that the ruptures avoided reticular fibers and interlobular septa made of connective tissue on the microscopic level. The present findings can be used for evaluation of HBM&apos;s of liver behavior in impact situations.

Název v anglickém jazyce

Blunt injury of liver - mechanical response of porcine liver in experimental impact test

Popis výsledku anglicky

Liver is frequently injured in blunt abdominal trauma caused by road traffic accidents. The testing of safety performance of vehicles, e.g. belt usage, head support, seat shape, or air bag shape, material, pressure, and reaction, could lead to reduction of the injury seriousness. Current trends in safety testing include development of accurate computational human body models (HBM&apos;s) based on the anatomical, morphological, and mechanical behavior of tissues under high strain. The aim of this study was to describe the internal pressure changes within porcine liver, the severity of liver injury and the relation between the porcine liver microstructure and rupture propagation in an experimental impact test. Porcine liver specimens (n = 24) were uniformly compressed using a drop tower technique and four impact heights (200, 300, 400 and 500 mm; corresponding velocities: 1.72, 2.17, 2.54, and 2.88 m/s). The changes in intravascular pressure were measured via catheters placed in portal vein and caudate vena cava. The induced injuries were analyzed on macroscopic level according to AAST grade and AIS severity. Rupture propagation with respect to liver microstructure was analyzed using stereological methods. Macroscopic ruptures affected mostly the interface between connective tissue surrounding big vessels and liver parenchyma. Histological analysis revealed that the ruptures avoided reticular fibers and interlobular septa made of connective tissue on the microscopic level. The present findings can be used for evaluation of HBM&apos;s of liver behavior in impact situations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30106 - Anatomy and morphology (plant science to be 1.6)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Measurement

ISSN

0967-3334

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

025008

Kód UT WoS článku

000627725600001

EID výsledku v databázi Scopus

2-s2.0-85102964002