Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10449437" target="_blank" >RIV/00669806:_____/22:10449437 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/22:10449437

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S4B1FEyjeM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S4B1FEyjeM</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines10102614" target="_blank" >10.3390/biomedicines10102614</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study

Popis výsledku v původním jazyce

Introduction: Asthma as a chronic inflammatory disorder has been suggested as a risk factor for endothelial dysfunction (ED), but studies on the association between asthma and cardiovascular disease (CVD) risk are limited. Background: We assessed associations of ED with the severity of asthma, eosinophilic inflammation, lung function, and asthma control. Methods: 52 young asthmatics (median age of 25.22 years) and 45 healthy individuals were included. Demographic, clinical , and laboratory findings were recorded. We evaluated microvascular responsiveness by recording the reactive hyperemia index (RHI) indicating post-occlusive peripheral endothelium -dependent changes in vascular tone using the Itamar Medical EndoPAT2000, VCAM-1, ADMA, high-sensitive CRP(hsCRP), and E-selectin werte measured. Results: Asthmatics had considerably lower RHI values (p&lt;0.001) with a dynamic decreasing trend by asthma severity and higher hsCRP levels (p&lt;0.001). A substantial increase in hsCRP and E-selectin with asthma severity (p&lt;0.05) was also observed. We confirmed a higher body mass index (BMI) in asthmatics (p&lt;0.001), especially in women and in severe asthma. Conclusions: We demonstrated the progression of CVD in asthmatics and the association of the ongoing deterioration of ED with the inflammatory severity, suggesting that the increased risk of CVD in young asthmatics is dependent on disease severity. The underlying mechanism of risk factors for CVD and disease control require further study.

Název v anglickém jazyce

Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study

Popis výsledku anglicky

Introduction: Asthma as a chronic inflammatory disorder has been suggested as a risk factor for endothelial dysfunction (ED), but studies on the association between asthma and cardiovascular disease (CVD) risk are limited. Background: We assessed associations of ED with the severity of asthma, eosinophilic inflammation, lung function, and asthma control. Methods: 52 young asthmatics (median age of 25.22 years) and 45 healthy individuals were included. Demographic, clinical , and laboratory findings were recorded. We evaluated microvascular responsiveness by recording the reactive hyperemia index (RHI) indicating post-occlusive peripheral endothelium -dependent changes in vascular tone using the Itamar Medical EndoPAT2000, VCAM-1, ADMA, high-sensitive CRP(hsCRP), and E-selectin werte measured. Results: Asthmatics had considerably lower RHI values (p&lt;0.001) with a dynamic decreasing trend by asthma severity and higher hsCRP levels (p&lt;0.001). A substantial increase in hsCRP and E-selectin with asthma severity (p&lt;0.05) was also observed. We confirmed a higher body mass index (BMI) in asthmatics (p&lt;0.001), especially in women and in severe asthma. Conclusions: We demonstrated the progression of CVD in asthmatics and the association of the ongoing deterioration of ED with the inflammatory severity, suggesting that the increased risk of CVD in young asthmatics is dependent on disease severity. The underlying mechanism of risk factors for CVD and disease control require further study.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicines [online]

ISSN

2227-9059

e-ISSN

2227-9059

Svazek periodika

10

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

17

Strana od-do

2614

Kód UT WoS článku

000872407400001

EID výsledku v databázi Scopus

2-s2.0-85140630011