Blood urea nitrogen - independent marker of mortality in sepsis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10445383" target="_blank" >RIV/00669806:_____/23:10445383 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00129989 RIV/00216208:11140/23:10445383

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ihp79hxJqn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ihp79hxJqn</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2022.015" target="_blank" >10.5507/bp.2022.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Blood urea nitrogen - independent marker of mortality in sepsis

Popis výsledku v původním jazyce

Background.This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clinical outcomes in patients with sepsis from two separate cohorts in the Czech Republic and the United States. Methods. The study included 9126 patients with sepsis between January 2014 and December 2018. Kaplan-Meier survival curves and Cox regression were used to analyse the data. An optimal cut-off was calculated by means of the Youden-Index. Results. BUN at ICU admission was categorized as 10-20, 20-40 and &gt;40 mg/dL. Comparing the group with the high-est BUN levels to the one with lowest levels, we found HR for 28 days mortality 2.764 (CI 95% 2.37-3.20; P&lt;0.001). We derived an optimal cut-off for prediction of 28 days mortality of 23 mg/dL. The association between BUN and 28 days mortality remained significant after adjusting for potential confounders - for APACHE IV (HR 1.374; 95%CI 1.20-1.58; P&lt;0.001), SAPS2 (HR 1.545; 95%CI 1.35-1.77; P&lt;0.001), eGFR (HR 1.851; 95%CI 1.59-2.16; P&lt;0.001) and several other variables in an integrative model. Conclusions. Our findings support the BUN level as an independent and easily available predictor of 28 days mortality in septic critically ill patients admitted to an ICU.

Název v anglickém jazyce

Blood urea nitrogen - independent marker of mortality in sepsis

Popis výsledku anglicky

Background.This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clinical outcomes in patients with sepsis from two separate cohorts in the Czech Republic and the United States. Methods. The study included 9126 patients with sepsis between January 2014 and December 2018. Kaplan-Meier survival curves and Cox regression were used to analyse the data. An optimal cut-off was calculated by means of the Youden-Index. Results. BUN at ICU admission was categorized as 10-20, 20-40 and &gt;40 mg/dL. Comparing the group with the high-est BUN levels to the one with lowest levels, we found HR for 28 days mortality 2.764 (CI 95% 2.37-3.20; P&lt;0.001). We derived an optimal cut-off for prediction of 28 days mortality of 23 mg/dL. The association between BUN and 28 days mortality remained significant after adjusting for potential confounders - for APACHE IV (HR 1.374; 95%CI 1.20-1.58; P&lt;0.001), SAPS2 (HR 1.545; 95%CI 1.35-1.77; P&lt;0.001), eGFR (HR 1.851; 95%CI 1.59-2.16; P&lt;0.001) and several other variables in an integrative model. Conclusions. Our findings support the BUN level as an independent and easily available predictor of 28 days mortality in septic critically ill patients admitted to an ICU.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30221 - Critical care medicine and Emergency medicine

Projekt

<a href="/cs/project/EF16_019%2F0000787" target="_blank" >EF16_019/0000787: Centrum výzkumu infekčních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

167

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

24-29

Kód UT WoS článku

000783230000001

EID výsledku v databázi Scopus

2-s2.0-85139771564