Assessment of Prostate Carcinoma Aggressiveness: Relation to (68)Ga-PSMA-11-PET/MRI and Gleason Score

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10452454" target="_blank" >RIV/00669806:_____/23:10452454 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/23:10452454

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5DDpsLVG-9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5DDpsLVG-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.16181" target="_blank" >10.21873/anticanres.16181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of Prostate Carcinoma Aggressiveness: Relation to (68)Ga-PSMA-11-PET/MRI and Gleason Score

Popis výsledku v původním jazyce

BACKGROUND/AIM: To test the correlation of (68)Ga-PSMA-11 uptake and the expression of PSMA (prostatic specific membrane antigen) with the Gleason score, apparent diffusion coefficient (ADC) and pharmacokinetic parameters obtained from dynamic contrast agent-enhanced MRI/PET. PATIENTS AND METHODS: Forty newly diagnosed, therapy naïve patients with prostatic carcinoma (PC) (mean age of 56.7, range=34-79), who were referred for (68)Ga-PSMA-11-PET/MRI for primary staging and had undergone radical prostatectomy (RAPE) were included in this prospective study. Their blood samples were tested for serum levels of prostate-specific antigen (PSA) and proPSA. The patients&apos; prostates were evaluated using whole-mount sections, which helped determine the extent and grade of the tumor; tests were performed to determine immunohistochemical PSMA expression. RESULTS: A correlation between PSMA expression and the accumulation of (68)Ga-PSMA-11 was found using the Spearman correlation coefficient (p=0.0011). A stronger correlation was found between Gleason patterns 3 or 4 and PSMA expression (p=0.06). Furthermore, the correlation of Gleason score with the overall (68)Ga-PSMA-11 accumulation within the tumor or non-tumor tissue was found to be significant (p=0.0157). A significant relation was found only with the K(ep) elimination rate constant, which was stronger in Gleason pattern 4 than in Gleason pattern 3. A weaker correlation was found between the accumulation of (68)Ga-PSMA-11 and K(trans) in Gleason pattern 4: the most significant relation being between ADC(min) and Gleason pattern 3 and 4 (p=0.0074). The total size of the tumor correlated with levels of proPSA (p&lt;0.0001), and its extra prostatic extension correlated with levels of proPSA (p&lt;0.0001). CONCLUSION: (68)Ga-PSMA-11 correlates well with the expression of PSMA. Gleason pattern 3 and 4 had a higher correlation with (68)Ga-PSMA-11 levels than did Gleason pattern 5. Either no correlation, or a weak correlation, was established with pharmacokinetics.

Název v anglickém jazyce

Assessment of Prostate Carcinoma Aggressiveness: Relation to (68)Ga-PSMA-11-PET/MRI and Gleason Score

Popis výsledku anglicky

BACKGROUND/AIM: To test the correlation of (68)Ga-PSMA-11 uptake and the expression of PSMA (prostatic specific membrane antigen) with the Gleason score, apparent diffusion coefficient (ADC) and pharmacokinetic parameters obtained from dynamic contrast agent-enhanced MRI/PET. PATIENTS AND METHODS: Forty newly diagnosed, therapy naïve patients with prostatic carcinoma (PC) (mean age of 56.7, range=34-79), who were referred for (68)Ga-PSMA-11-PET/MRI for primary staging and had undergone radical prostatectomy (RAPE) were included in this prospective study. Their blood samples were tested for serum levels of prostate-specific antigen (PSA) and proPSA. The patients&apos; prostates were evaluated using whole-mount sections, which helped determine the extent and grade of the tumor; tests were performed to determine immunohistochemical PSMA expression. RESULTS: A correlation between PSMA expression and the accumulation of (68)Ga-PSMA-11 was found using the Spearman correlation coefficient (p=0.0011). A stronger correlation was found between Gleason patterns 3 or 4 and PSMA expression (p=0.06). Furthermore, the correlation of Gleason score with the overall (68)Ga-PSMA-11 accumulation within the tumor or non-tumor tissue was found to be significant (p=0.0157). A significant relation was found only with the K(ep) elimination rate constant, which was stronger in Gleason pattern 4 than in Gleason pattern 3. A weaker correlation was found between the accumulation of (68)Ga-PSMA-11 and K(trans) in Gleason pattern 4: the most significant relation being between ADC(min) and Gleason pattern 3 and 4 (p=0.0074). The total size of the tumor correlated with levels of proPSA (p&lt;0.0001), and its extra prostatic extension correlated with levels of proPSA (p&lt;0.0001). CONCLUSION: (68)Ga-PSMA-11 correlates well with the expression of PSMA. Gleason pattern 3 and 4 had a higher correlation with (68)Ga-PSMA-11 levels than did Gleason pattern 5. Either no correlation, or a weak correlation, was established with pharmacokinetics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

1791-7530

Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

449-453

Kód UT WoS článku

000974291900055

EID výsledku v databázi Scopus

2-s2.0-85145287456