Are all HCL systems the same? Long term outcomes of three HCL systems in children with type 1 diabetes: real-life registry-based study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10469631" target="_blank" >RIV/00669806:_____/23:10469631 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10469631 RIV/00216208:11110/23:10469631 RIV/00216208:11320/23:10469631 RIV/00216208:11140/23:10469631 a 6 dalších

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9hE2dttbSw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9hE2dttbSw</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2023.1283181" target="_blank" >10.3389/fendo.2023.1283181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Are all HCL systems the same? Long term outcomes of three HCL systems in children with type 1 diabetes: real-life registry-based study

Popis výsledku v původním jazyce

Objective: To compare parameters of glycemic control among three types of hybrid closed loop (HCL) systems in children with T1D (CwD) using population-wide data from the national pediatric diabetes registry ČENDA. Methods: CwD aged &lt;19 years treated with Medtronic MiniMed 780G, Tandem t:slim X2 (Control-IQ) or do-it-yourself AndroidAPS (AAPS) systems for &gt;12 months and monitored by CGM&gt;70% of the time were included. HbA1c, times in glycemic rangers, and Glycemia Risk Index (GRI) were used for cross-sectional comparison between the HCL systems.Results: Data from 512 CwD were analyzed. 780G, Control-IQ and AAPS were used by 217 (42,4%), 211 (41,2%), and 84 (16.4%) CwD, respectively. The lowest HbA1c value was observed in the AAPS group (44mmol/mol; OQR 8.0, p&lt;0.0001 vs any other group), followed by Control-IQ and 780G groups (48 (IQR 11) and 52 (OQR 10) mmol/mol, respectively). All of the systems met the recommended criteria for time in range (78% in AAPS, 76% in 780G, and 75% in Control-IQ users). CwD using AAPS spent significantly more time in hypoglycemia (5% vs 2% in 780G and 3% in Control-IQ) and scored the highest GRI (32, IQR 17). The lowest GRI (27, IQR 15) was seen in 780G users. Conclusion: Although all HCL systems proved effective in maintaining recommended long-tserm glycemic control, we observed differences that illustrate strengths and weaknesses of particular systems. Our fingings could help in individualizing the choice of HCL systems.

Název v anglickém jazyce

Are all HCL systems the same? Long term outcomes of three HCL systems in children with type 1 diabetes: real-life registry-based study

Popis výsledku anglicky

Objective: To compare parameters of glycemic control among three types of hybrid closed loop (HCL) systems in children with T1D (CwD) using population-wide data from the national pediatric diabetes registry ČENDA. Methods: CwD aged &lt;19 years treated with Medtronic MiniMed 780G, Tandem t:slim X2 (Control-IQ) or do-it-yourself AndroidAPS (AAPS) systems for &gt;12 months and monitored by CGM&gt;70% of the time were included. HbA1c, times in glycemic rangers, and Glycemia Risk Index (GRI) were used for cross-sectional comparison between the HCL systems.Results: Data from 512 CwD were analyzed. 780G, Control-IQ and AAPS were used by 217 (42,4%), 211 (41,2%), and 84 (16.4%) CwD, respectively. The lowest HbA1c value was observed in the AAPS group (44mmol/mol; OQR 8.0, p&lt;0.0001 vs any other group), followed by Control-IQ and 780G groups (48 (IQR 11) and 52 (OQR 10) mmol/mol, respectively). All of the systems met the recommended criteria for time in range (78% in AAPS, 76% in 780G, and 75% in Control-IQ users). CwD using AAPS spent significantly more time in hypoglycemia (5% vs 2% in 780G and 3% in Control-IQ) and scored the highest GRI (32, IQR 17). The lowest GRI (27, IQR 15) was seen in 780G users. Conclusion: Although all HCL systems proved effective in maintaining recommended long-tserm glycemic control, we observed differences that illustrate strengths and weaknesses of particular systems. Our fingings could help in individualizing the choice of HCL systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Endocrinology

ISSN

1664-2392

e-ISSN

1664-2392

Svazek periodika

14

Číslo periodika v rámci svazku

OCT

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

1283181

Kód UT WoS článku

001094057600001

EID výsledku v databázi Scopus

2-s2.0-85175380328