Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F24%3A10470922" target="_blank" >RIV/00669806:_____/24:10470922 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/24:10470922
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b7kLHdso~K" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b7kLHdso~K</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00431-023-05324-2" target="_blank" >10.1007/s00431-023-05324-2</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views
Popis výsledku v původním jazyce
We would like to provide an updated comprehensive perspective and identify the components linked to chronic spontaneous urticaria (CSU) without specific triggers in autoimmune atrophic gastritis (AAG). AAG is an organ-specific autoimmune disease that affects the corpus-fundus gastric mucosa. Although we lack a unified explanation of the underlying pathways, when considering all paediatric patients reported in the literature, alterations reslult in gastric neuroendocrine enterochrmaffin-like (ECL) cell proliferation and paracrine release of histamine. Several mechanism have been proposed for the pathogenesis of CSU, with much evidence pointing towards AAG and ECL cell responses, which may be implicated as potential factors contributing to CSU. The excessive production/release of histamine into the bloodstream could cause or trigger exacerbations of CSU in AAG, independent of Helicobacter pylori; thus, the release of histamine from ECL cells may be the primary modulator. Conclusion: Considering the understanding of these interactions, recognising the respective roles of AAG in the pathogenesis of CSU may strongly impactt the diagnostic workup and management of unexplained/refractory CSU and may inform future research and interventions in the paediatric population.
Název v anglickém jazyce
Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views
Popis výsledku anglicky
We would like to provide an updated comprehensive perspective and identify the components linked to chronic spontaneous urticaria (CSU) without specific triggers in autoimmune atrophic gastritis (AAG). AAG is an organ-specific autoimmune disease that affects the corpus-fundus gastric mucosa. Although we lack a unified explanation of the underlying pathways, when considering all paediatric patients reported in the literature, alterations reslult in gastric neuroendocrine enterochrmaffin-like (ECL) cell proliferation and paracrine release of histamine. Several mechanism have been proposed for the pathogenesis of CSU, with much evidence pointing towards AAG and ECL cell responses, which may be implicated as potential factors contributing to CSU. The excessive production/release of histamine into the bloodstream could cause or trigger exacerbations of CSU in AAG, independent of Helicobacter pylori; thus, the release of histamine from ECL cells may be the primary modulator. Conclusion: Considering the understanding of these interactions, recognising the respective roles of AAG in the pathogenesis of CSU may strongly impactt the diagnostic workup and management of unexplained/refractory CSU and may inform future research and interventions in the paediatric population.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30209 - Paediatrics
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
European Journal of Pediatrics
ISSN
0340-6199
e-ISSN
1432-1076
Svazek periodika
183
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
8
Strana od-do
515-522
Kód UT WoS článku
001100533400001
EID výsledku v databázi Scopus
2-s2.0-85176545925