HIV disease metrics and COVID-19 infection severity and outcomes in people living with HIV in central and eastern Europe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F24%3A10472012" target="_blank" >RIV/00669806:_____/24:10472012 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10472012 RIV/00216208:11140/24:10472012 RIV/00064211:_____/24:W0000051

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yTKgi-cmvz" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yTKgi-cmvz</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/hiv.13578" target="_blank" >10.1111/hiv.13578</a>

Jazyk výsledku

angličtina

Název v původním jazyce

HIV disease metrics and COVID-19 infection severity and outcomes in people living with HIV in central and eastern Europe

Popis výsledku v původním jazyce

BackgroundTo date there remains much ambiguity in the literature regarding the immunological interplay between SARS-CoV-2 and HIV and the true risk posed to coinfected individuals. There has been little conclusive data regarding the use of CD4 cell count and HIV viral load stratification as predictors of COVID-19 severity in this cohort.MethodsWe performed a retrospective, observational cohort study on people living with HIV (PLWH) who contracted COVID-19 in central and eastern Europe. We enrolled 536 patients from 16 countries using an online survey. We evaluated patient demographics, HIV characteristics and COVID-19 presentation and outcomes. Statistical analysis was performed using SPSS 20.1.ResultsThe majority of the study cohort were male (76.4%) and 152 (28.3%) had a significant medical comorbidity. Median CD4 cell count at COVID-19 diagnosis was 605 cells/μL [interquartile range (IQR) 409-824]. The majority of patients on antiretroviral therapy (ART) were virally suppressed (92%). In univariate analysis, CD4 cell count &lt;350 cells/μL was associated with higher rates of hospitalization (p &lt; 0.0001) and respiratory failure (p &lt; 0.0001). Univariate and multivariate analyses found that an undetectable HIV VL was associated with a lower rate of hospitalization (p &lt; 0.0001), respiratory failure (p &lt; 0.0001), ICU admission or death (p &lt; 0.0001), and with a higher chance of full recovery (p &lt; 0.0001).ConclusionWe can conclude that detectable HIV viral load was an independent risk factor for severe COVID-19 illness and can be used as a prognostic indicator in this cohort.

Název v anglickém jazyce

HIV disease metrics and COVID-19 infection severity and outcomes in people living with HIV in central and eastern Europe

Popis výsledku anglicky

BackgroundTo date there remains much ambiguity in the literature regarding the immunological interplay between SARS-CoV-2 and HIV and the true risk posed to coinfected individuals. There has been little conclusive data regarding the use of CD4 cell count and HIV viral load stratification as predictors of COVID-19 severity in this cohort.MethodsWe performed a retrospective, observational cohort study on people living with HIV (PLWH) who contracted COVID-19 in central and eastern Europe. We enrolled 536 patients from 16 countries using an online survey. We evaluated patient demographics, HIV characteristics and COVID-19 presentation and outcomes. Statistical analysis was performed using SPSS 20.1.ResultsThe majority of the study cohort were male (76.4%) and 152 (28.3%) had a significant medical comorbidity. Median CD4 cell count at COVID-19 diagnosis was 605 cells/μL [interquartile range (IQR) 409-824]. The majority of patients on antiretroviral therapy (ART) were virally suppressed (92%). In univariate analysis, CD4 cell count &lt;350 cells/μL was associated with higher rates of hospitalization (p &lt; 0.0001) and respiratory failure (p &lt; 0.0001). Univariate and multivariate analyses found that an undetectable HIV VL was associated with a lower rate of hospitalization (p &lt; 0.0001), respiratory failure (p &lt; 0.0001), ICU admission or death (p &lt; 0.0001), and with a higher chance of full recovery (p &lt; 0.0001).ConclusionWe can conclude that detectable HIV viral load was an independent risk factor for severe COVID-19 illness and can be used as a prognostic indicator in this cohort.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

HIV Medicine

ISSN

1464-2662

e-ISSN

1468-1293

Svazek periodika

25

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

343-352

Kód UT WoS článku

001114885300001

EID výsledku v databázi Scopus

2-s2.0-85178073614