Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F25%3A10500689" target="_blank" >RIV/00669806:_____/25:10500689 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/25:10500689

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yB-XR~UV_X" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yB-XR~UV_X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/ehaf430" target="_blank" >10.1093/eurheartj/ehaf430</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study

Popis výsledku v původním jazyce

Background and Aims Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants. Methods This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants-COVID-19-negative controls (i) and three groups of individuals with recent (6 +/- 3 months) exposure to SARS-CoV-2: not hospitalized (ii), hospitalized in general wards (iii), and hospitalized in intensive care units (iv). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness. Results 2390 individuals (age 50 +/- 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40 m/s for groups 2-4, P &lt; .001, P = .001 and P = .003) vs. controls [PWV 7.53 (7.09; 7.97) m/s adjusted mean (95% CI)]. In sex-stratified analyses, PWV differences were significant in women [PWV (+0.55, +0.60, and +1.09 m/s for groups 2-4, P &lt; .001 for all)], but not in men. Among COVID-19 positive women, persistent symptoms were associated with higher PWV, regardless of disease severity and cardiovascular confounders [adjusted PWV 7.52 (95% CI 7.09; 7.96) vs. 7.13 (95% CI 6.67; 7.59) m/s, P &lt; .001]. A stable or improved PWV after 12 months was found in the COVID+ groups, whereas a progression was observed in the COVID- group. Conclusions COVID-19 is associated with early vascular ageing in the long term, especially in women.

Název v anglickém jazyce

Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study

Popis výsledku anglicky

Background and Aims Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants. Methods This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants-COVID-19-negative controls (i) and three groups of individuals with recent (6 +/- 3 months) exposure to SARS-CoV-2: not hospitalized (ii), hospitalized in general wards (iii), and hospitalized in intensive care units (iv). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness. Results 2390 individuals (age 50 +/- 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40 m/s for groups 2-4, P &lt; .001, P = .001 and P = .003) vs. controls [PWV 7.53 (7.09; 7.97) m/s adjusted mean (95% CI)]. In sex-stratified analyses, PWV differences were significant in women [PWV (+0.55, +0.60, and +1.09 m/s for groups 2-4, P &lt; .001 for all)], but not in men. Among COVID-19 positive women, persistent symptoms were associated with higher PWV, regardless of disease severity and cardiovascular confounders [adjusted PWV 7.52 (95% CI 7.09; 7.96) vs. 7.13 (95% CI 6.67; 7.59) m/s, P &lt; .001]. A stable or improved PWV after 12 months was found in the COVID+ groups, whereas a progression was observed in the COVID- group. Conclusions COVID-19 is associated with early vascular ageing in the long term, especially in women.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Heart Journal

ISSN

0195-668X

e-ISSN

1522-9645

Svazek periodika

46

Číslo periodika v rámci svazku

39

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

3905-3918

Kód UT WoS článku

001552455800001

EID výsledku v databázi Scopus

2-s2.0-105018789737