Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F25%3A10501176" target="_blank" >RIV/00669806:_____/25:10501176 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/25:10501176

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vsWZ1GB56p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vsWZ1GB56p</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ncrna.2025.07.006" target="_blank" >10.1016/j.ncrna.2025.07.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

Popis výsledku v původním jazyce

Background &amp; Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin (CTNNB1), tumor protein p53 (TP53), and telomerase reverse transcriptase promoter (TERTp) are well-documented in the literature, dysregulation of microRNAs (miRNAs), small non-coding RNAs that serve as crucial translational regulators, remains poorly understood. Methods: We conducted microRNA profiling by microarrays in 45 paired (tumor and non-tumor adjacent tissue) samples from non-viral HCC patients. We performed clinical correlation, ROC analysis and survival analysis of time to recurrence (TTR), disease-free survival (DFS) and overall survival. Results: We identified 23 significantly dysregulated miRNAs (p &lt;= 0.05, fold change &gt;=2). We investigated their differential expression and its relationship with clinical and pathological variables. Further, we found that miRNA-1972 may serve as an important positive prognostic marker because its high levels were associated with longer TTR and DFS. Significant positive results were obtained in receiver operating characteristic analysis for miR-1972, miR-3651 and miR-486-5p. Conclusion: miRNA-1972 is a strong prognostic marker in non-viral HCC. Dysregulation of several other miRNAs relates to pathological variables such as amount of stroma within tumor, microvascular invasion and micronodularity.

Název v anglickém jazyce

Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

Popis výsledku anglicky

Background &amp; Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin (CTNNB1), tumor protein p53 (TP53), and telomerase reverse transcriptase promoter (TERTp) are well-documented in the literature, dysregulation of microRNAs (miRNAs), small non-coding RNAs that serve as crucial translational regulators, remains poorly understood. Methods: We conducted microRNA profiling by microarrays in 45 paired (tumor and non-tumor adjacent tissue) samples from non-viral HCC patients. We performed clinical correlation, ROC analysis and survival analysis of time to recurrence (TTR), disease-free survival (DFS) and overall survival. Results: We identified 23 significantly dysregulated miRNAs (p &lt;= 0.05, fold change &gt;=2). We investigated their differential expression and its relationship with clinical and pathological variables. Further, we found that miRNA-1972 may serve as an important positive prognostic marker because its high levels were associated with longer TTR and DFS. Significant positive results were obtained in receiver operating characteristic analysis for miR-1972, miR-3651 and miR-486-5p. Conclusion: miRNA-1972 is a strong prognostic marker in non-viral HCC. Dysregulation of several other miRNAs relates to pathological variables such as amount of stroma within tumor, microvascular invasion and micronodularity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LX22NPO5102" target="_blank" >LX22NPO5102: Národní ústav pro výzkum rakoviny</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Non-coding RNA Research

ISSN

2468-2160

e-ISSN

2468-0540

Svazek periodika

15

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

8

Strana od-do

100-107

Kód UT WoS článku

001577029500001

EID výsledku v databázi Scopus

2-s2.0-105013465475