Dipeptid prolyl-hydroxyprolin v nehydrolyzované moči a jeho význam v postmenopausální osteoporóze

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F08%3A00016006" target="_blank" >RIV/00843989:_____/08:00016006 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/08:00326361

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis

Popis výsledku v původním jazyce

High correlation between the level of prolyl-4-hydroxyproline dipeptide in non-hydrolyzed urine and that of 4-hydroxyproline in hydrolyzed urine might reveal the dipeptide as a valuable osteomarker. Based on densitometry, 68 postmenopausal women were divided into group of non-osteopathic, osteopenic and osteoporotic subjects. The dipeptide and current urinary resorption markers were assayed in morning urine, serum formation markers by means of immunoassay procedures. Along with the assay of the basal levels, diet-related changes and the healing effect of yearly alendronate therapy were assessed. Concentration levels in controls and osteoporotic subjects differed significantly; ROC analysis gave sensitivity of 0.743 and cut-off 10.2 ?mol/mmol of creatinine. Diet-related changes were not found. Following the therapy, a significant decline occurred already within a trimester. The ease of the dipeptide assay surpass that of hydroxyproline, the dipeptide can serve as a valuable osteomarker.

Název v anglickém jazyce

Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis

Popis výsledku anglicky

High correlation between the level of prolyl-4-hydroxyproline dipeptide in non-hydrolyzed urine and that of 4-hydroxyproline in hydrolyzed urine might reveal the dipeptide as a valuable osteomarker. Based on densitometry, 68 postmenopausal women were divided into group of non-osteopathic, osteopenic and osteoporotic subjects. The dipeptide and current urinary resorption markers were assayed in morning urine, serum formation markers by means of immunoassay procedures. Along with the assay of the basal levels, diet-related changes and the healing effect of yearly alendronate therapy were assessed. Concentration levels in controls and osteoporotic subjects differed significantly; ROC analysis gave sensitivity of 0.743 and cut-off 10.2 ?mol/mmol of creatinine. Diet-related changes were not found. Following the therapy, a significant decline occurred already within a trimester. The ease of the dipeptide assay surpass that of hydroxyproline, the dipeptide can serve as a valuable osteomarker.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/NR8948" target="_blank" >NR8948: Snadné a finančně nenáročné stanovení dipeptidu Pro-Hyp v nehydrolyzované moči a jeho možná významná role jako biomarkeru kostní resorpce</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000259929400008

EID výsledku v databázi Scopus

—