A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F09%3A00100617" target="_blank" >RIV/00843989:_____/09:00100617 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept?

Popis výsledku v původním jazyce

Excessive forms of the response of an organism to infection play an important role in the pathogenesis of severe sepsis. They may consist of either a local pro-inflammatory response with the massive release of cytokines into the systemic circulation, ormay be presented with an excessive systemic anti-inflammatory response. In the first case, the result is a systemic pro-inflammatory state, characterised by a natural stages of the inflammatory response in which dysfunction of macrocirculation is followed by microcirculation derangement and mitochondrial alteration at the end. These mechanisms are responsible for the development of remote organs failure. The result in the second case is a deactivation of local immunocompetent cells, which results in therisk of uncontrollable growth of microorganisms, especially in organs with impaired antimicrobial barrier. This may explain the clinically observed recurrence of septic episodes, when a resolution of infection on one site is later repla

Název v anglickém jazyce

A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept?

Popis výsledku anglicky

Excessive forms of the response of an organism to infection play an important role in the pathogenesis of severe sepsis. They may consist of either a local pro-inflammatory response with the massive release of cytokines into the systemic circulation, ormay be presented with an excessive systemic anti-inflammatory response. In the first case, the result is a systemic pro-inflammatory state, characterised by a natural stages of the inflammatory response in which dysfunction of macrocirculation is followed by microcirculation derangement and mitochondrial alteration at the end. These mechanisms are responsible for the development of remote organs failure. The result in the second case is a deactivation of local immunocompetent cells, which results in therisk of uncontrollable growth of microorganisms, especially in organs with impaired antimicrobial barrier. This may explain the clinically observed recurrence of septic episodes, when a resolution of infection on one site is later repla

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Svazek periodika

110

Číslo periodika v rámci svazku

no.8

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000269177400003

EID výsledku v databázi Scopus

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