Relation between TGF-ß 1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00100917" target="_blank" >RIV/00843989:_____/10:00100917 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Relation between TGF-ß 1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus

Popis výsledku v původním jazyce

Therapy of posthemorrhagic hydrocephalus (PHH) by using ventriculo-peritoneal drainage bears considerable rate of complications and remains a challenge in premature newborns. The role of endoscopic third ventriculostomy (ETV) in these patients is unclear, through obstruction is proved in some patients with PHH.TGF ? 1 release into the CSF in time of primary bleeding is suggested as one of possible pathophysiologic reasons of PHH formation. Relation between TGF ?1 levels and ETV success rate has not beenreported yet. The aim of our study is to detect group of patients, according to the levels of TGF ?1, who have MRI proved obstruction hydrocefalus without participation of hyporesorption ? so that we can expect success of ETV. MethodsWe followed 29 premature newborns with PHH during 2005-2007, all of them treated by Ommaya reservoir implantation and repeated taps with TGF ?1 levels examination. In case of persisting hydrocephalus MRI was performed. In 16 patients with proved

Název v anglickém jazyce

Relation between TGF-ß 1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus

Popis výsledku anglicky

Therapy of posthemorrhagic hydrocephalus (PHH) by using ventriculo-peritoneal drainage bears considerable rate of complications and remains a challenge in premature newborns. The role of endoscopic third ventriculostomy (ETV) in these patients is unclear, through obstruction is proved in some patients with PHH.TGF ? 1 release into the CSF in time of primary bleeding is suggested as one of possible pathophysiologic reasons of PHH formation. Relation between TGF ?1 levels and ETV success rate has not beenreported yet. The aim of our study is to detect group of patients, according to the levels of TGF ?1, who have MRI proved obstruction hydrocefalus without participation of hyporesorption ? so that we can expect success of ETV. MethodsWe followed 29 premature newborns with PHH during 2005-2007, all of them treated by Ommaya reservoir implantation and repeated taps with TGF ?1 levels examination. In case of persisting hydrocephalus MRI was performed. In 16 patients with proved

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Child's nervous system

ISSN

0256-7040

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000274500800009

EID výsledku v databázi Scopus

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