Early regression of the dental lamina underlies the development of diphyodont dentitions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102393" target="_blank" >RIV/00843989:_____/12:00102393 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/12:00379143 RIV/62157124:16170/12:43871657

Výsledek na webu

<a href="http://dx.doi.org/10.1177/0022034512442896" target="_blank" >http://dx.doi.org/10.1177/0022034512442896</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0022034512442896" target="_blank" >10.1177/0022034512442896</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Early regression of the dental lamina underlies the development of diphyodont dentitions

Popis výsledku v původním jazyce

Functional tooth germs in mammals, reptiles, and chondrichthyans are initiated from a dental lamina. The longevity of the lamina plays a role in governing the number of tooth generations. Monophyodont species have no replacement dental lamina, while polyphyodont species have a permanent continuous lamina. In diphyodont species, the dental lamina fragments and regresses after initiation of the second tooth generation. Regression of the lamina seems to be an important mechanism in preventing the further development of replacement teeth. Defects in the complete removal of the lamina lead to cyst formation and has been linked to ameloblastomas. Here, we show the previously unknown mechanisms behind the disappearance of the dental lamina, involving a combination of cell migration, cell-fate transformation, and apoptosis. Lamina regression starts with the loss of the basement membrane, allowing the epithelial cells to break away from the lamina and migrate into the surrounding mesenchyme. Ce

Název v anglickém jazyce

Early regression of the dental lamina underlies the development of diphyodont dentitions

Popis výsledku anglicky

Functional tooth germs in mammals, reptiles, and chondrichthyans are initiated from a dental lamina. The longevity of the lamina plays a role in governing the number of tooth generations. Monophyodont species have no replacement dental lamina, while polyphyodont species have a permanent continuous lamina. In diphyodont species, the dental lamina fragments and regresses after initiation of the second tooth generation. Regression of the lamina seems to be an important mechanism in preventing the further development of replacement teeth. Defects in the complete removal of the lamina lead to cyst formation and has been linked to ameloblastomas. Here, we show the previously unknown mechanisms behind the disappearance of the dental lamina, involving a combination of cell migration, cell-fate transformation, and apoptosis. Lamina regression starts with the loss of the basement membrane, allowing the epithelial cells to break away from the lamina and migrate into the surrounding mesenchyme. Ce

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/KJB601110910" target="_blank" >KJB601110910: Vývojové a evoluční aspekty polyfyodontní a heterodontní dentice u plazů</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of dental research

ISSN

0022-0345

e-ISSN

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Svazek periodika

91

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

491-498

Kód UT WoS článku

000302916300010

EID výsledku v databázi Scopus

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