Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0103633" target="_blank" >RIV/00843989:_____/13:E0103633 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/13:A14019L3 RIV/65269705:_____/13:#0002092 RIV/00216224:14110/13:00065642

Výsledek na webu

<a href="http://dx.doi.org/10.1111/bjh.12563" target="_blank" >http://dx.doi.org/10.1111/bjh.12563</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bjh.12563" target="_blank" >10.1111/bjh.12563</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

Popis výsledku v původním jazyce

Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treatwith a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure

Název v anglickém jazyce

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

Popis výsledku anglicky

Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treatwith a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British journal of haematology

ISSN

0007-1048

e-ISSN

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Svazek periodika

163

Číslo periodika v rámci svazku

n. 5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

"p. 551-564"

Kód UT WoS článku

000326807400003

EID výsledku v databázi Scopus

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