No-option critical limb ischemia revascularization with stem cell therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0104172" target="_blank" >RIV/00843989:_____/14:E0104172 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

No-option critical limb ischemia revascularization with stem cell therapy

Popis výsledku v původním jazyce

AIM AND METHODS: Peripheral arterial occlusive disease (PAOD) has been recognized as a significant factor in the population of patients with critical limb ischemia. In total 49% of patients presenting with a new diabetic foot ulcer had PAOD. Critical limb ischemia (CLI) develops suddenly, and is responsible for 50-67% of all nontraumatic lower extremity amputations. Fifty two per cent of diabetics with CLI die during the 4.5-year follow-up. The SmartPreP2 centrifuge gradient density centrifugation resulted in at least a 7.16 fold concentration of CD34+ cells in the bone marrow concentrate and more than 6.2 fold concentration of mononuclear cells (compared to a sample of BMA aspirate before centrifugation). The gradient density centrifugation increasedthe concentration of platelets about 3.9 fold while preserving the relative concentrations of other cells in the host BMAC. The procedure of stem cells transplantation is performed under intravenous single-shot antibiotics, in order to av

Název v anglickém jazyce

No-option critical limb ischemia revascularization with stem cell therapy

Popis výsledku anglicky

AIM AND METHODS: Peripheral arterial occlusive disease (PAOD) has been recognized as a significant factor in the population of patients with critical limb ischemia. In total 49% of patients presenting with a new diabetic foot ulcer had PAOD. Critical limb ischemia (CLI) develops suddenly, and is responsible for 50-67% of all nontraumatic lower extremity amputations. Fifty two per cent of diabetics with CLI die during the 4.5-year follow-up. The SmartPreP2 centrifuge gradient density centrifugation resulted in at least a 7.16 fold concentration of CD34+ cells in the bone marrow concentrate and more than 6.2 fold concentration of mononuclear cells (compared to a sample of BMA aspirate before centrifugation). The gradient density centrifugation increasedthe concentration of platelets about 3.9 fold while preserving the relative concentrations of other cells in the host BMAC. The procedure of stem cells transplantation is performed under intravenous single-shot antibiotics, in order to av

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Italian Journal of Vascular and Endovascular Surgery

ISSN

1824-4777

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

n. 4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

10

Strana od-do

"p. 191-200"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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