Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F15%3A0104669A" target="_blank" >RIV/00843989:_____/15:0104669A - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/15:E0104669

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijporl.2015.02.013" target="_blank" >http://dx.doi.org/10.1016/j.ijporl.2015.02.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijporl.2015.02.013" target="_blank" >10.1016/j.ijporl.2015.02.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest

Popis výsledku v původním jazyce

INTRODUCTION: The aim of the study was to investigate whether Peptest, an immunoassay used to detect pepsin, could be used to diagnose extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME). The results obtained using this fast, simple and non-expensive method were compared with the results of previous studies. METHODS: Children 1-7 years old who had been diagnosed with OME and who were undergoing myringotomy with insertion of a ventilation tube were included in the prospective study. Middle ear fluid obtained during myringotomy was analyzed with Peptest to determine the presence of pepsin, and hence EER. RESULTS: Bilateral and unilateral myringotomy was performed in 15/44 (34.1%) and 29/44 (65.9%) children, respectively. Pepsin in the middle ear was detected in 14/44 (31.8%) children and in 19/59 (32.2%) middle ear specimens. Serous and mucous samples were positive for pepsin in 11/32 (34.4%) and 6/27 (22.2%) cases, respectively. Pepsin in the middle ear was detected in 3/7 children (42.9%) with bronchial asthma (p=0.662). CONCLUSIONS: Pepsin was detected in 1/3 of middle ear specimens of patients with OME. These patients probably suffer from more severe reflux and therefore would be potential candidates for antireflux therapy. However, this has to be confirmed in further studies.

Název v anglickém jazyce

Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest

Popis výsledku anglicky

INTRODUCTION: The aim of the study was to investigate whether Peptest, an immunoassay used to detect pepsin, could be used to diagnose extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME). The results obtained using this fast, simple and non-expensive method were compared with the results of previous studies. METHODS: Children 1-7 years old who had been diagnosed with OME and who were undergoing myringotomy with insertion of a ventilation tube were included in the prospective study. Middle ear fluid obtained during myringotomy was analyzed with Peptest to determine the presence of pepsin, and hence EER. RESULTS: Bilateral and unilateral myringotomy was performed in 15/44 (34.1%) and 29/44 (65.9%) children, respectively. Pepsin in the middle ear was detected in 14/44 (31.8%) children and in 19/59 (32.2%) middle ear specimens. Serous and mucous samples were positive for pepsin in 11/32 (34.4%) and 6/27 (22.2%) cases, respectively. Pepsin in the middle ear was detected in 3/7 children (42.9%) with bronchial asthma (p=0.662). CONCLUSIONS: Pepsin was detected in 1/3 of middle ear specimens of patients with OME. These patients probably suffer from more severe reflux and therefore would be potential candidates for antireflux therapy. However, this has to be confirmed in further studies.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13500" target="_blank" >NT13500: Diagnostika extraezofageálního refluxu pomocí systému Restech u pacientů s chronickou rinosinusitidou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of pediatric otorhinolaryngology

ISSN

0165-5876

e-ISSN

—

Svazek periodika

79

Číslo periodika v rámci svazku

n. 5

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

3

Strana od-do

"p. 677-679"

Kód UT WoS článku

000353604600009

EID výsledku v databázi Scopus

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