Sonolysis in prevention of brain infarction during cardiac surgery (SONORESCUE)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105503" target="_blank" >RIV/00843989:_____/16:E0105503 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MD.0000000000003615" target="_blank" >http://dx.doi.org/10.1097/MD.0000000000003615</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MD.0000000000003615" target="_blank" >10.1097/MD.0000000000003615</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sonolysis in prevention of brain infarction during cardiac surgery (SONORESCUE)

Popis výsledku v původním jazyce

Here, we examined whether intraoperative sonolysis can alter the risk of new ischemic lesions in the insonated brain artery territory during coronary artery bypass grafting (CABG) or valve surgery.Silent brain ischemic lesions could be detected in as many as two-thirds of patients after CABG or valve surgery.Patients indicated for CABG or valve surgery were allocated randomly to sonolysis (60 patients, 37 males; mean age, 65.3 years) of the right middle cerebral artery (MCA) during cardiac surgery and control group (60 patients, 37 males; mean age, 65.3 years). Neurologic examination, cognitive function tests, and brain magnetic resonance imaging (MRI) were conducted before intervention as well as 24 to 72?hours and 30 days after surgery.New ischemic lesions on control diffusion-weighted MRI in the insonated MCA territory ?0.5?mL were significantly less frequent in the sonolysis group than in the control group (13.3% vs 26.7%, P?=?0.109). The sonolysis group exhibited significantly reduced median volume of new brain ischemic lesions (P?=?0.026). Stenosis of the internal carotid artery ?50% and smoking were independent predictors of new brain ischemic lesions ?0.5?mL (odds ratio?=?5.685 [1.272-25.409], P?=?0.023 and 4.698 [1.092-20.208], P?=?0.038, respectively). Stroke or transient ischemic attack occurred only in 2 control patients (P?=?0.496). No significant differences were found in scores for postintervention cognitive tests (P?>?0.05).This study provides class-II evidence that sonolysis during CABG or valve surgery reduces the risk of larger, new ischemic lesions in the brain

Název v anglickém jazyce

Sonolysis in prevention of brain infarction during cardiac surgery (SONORESCUE)

Popis výsledku anglicky

Here, we examined whether intraoperative sonolysis can alter the risk of new ischemic lesions in the insonated brain artery territory during coronary artery bypass grafting (CABG) or valve surgery.Silent brain ischemic lesions could be detected in as many as two-thirds of patients after CABG or valve surgery.Patients indicated for CABG or valve surgery were allocated randomly to sonolysis (60 patients, 37 males; mean age, 65.3 years) of the right middle cerebral artery (MCA) during cardiac surgery and control group (60 patients, 37 males; mean age, 65.3 years). Neurologic examination, cognitive function tests, and brain magnetic resonance imaging (MRI) were conducted before intervention as well as 24 to 72?hours and 30 days after surgery.New ischemic lesions on control diffusion-weighted MRI in the insonated MCA territory ?0.5?mL were significantly less frequent in the sonolysis group than in the control group (13.3% vs 26.7%, P?=?0.109). The sonolysis group exhibited significantly reduced median volume of new brain ischemic lesions (P?=?0.026). Stenosis of the internal carotid artery ?50% and smoking were independent predictors of new brain ischemic lesions ?0.5?mL (odds ratio?=?5.685 [1.272-25.409], P?=?0.023 and 4.698 [1.092-20.208], P?=?0.038, respectively). Stroke or transient ischemic attack occurred only in 2 control patients (P?=?0.496). No significant differences were found in scores for postintervention cognitive tests (P?>?0.05).This study provides class-II evidence that sonolysis during CABG or valve surgery reduces the risk of larger, new ischemic lesions in the brain

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13498" target="_blank" >NT13498: Snížení rizika vzniku symptomatického a klinicky němého mozkového infarktu v průběhu kardiochirurgické operace pomocí aktivace fibrinolytického systému kontinuálním transkraniálním dopplerovským monitoringem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicine

ISSN

0025-7974

e-ISSN

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Svazek periodika

95

Číslo periodika v rámci svazku

n. 20

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

"p. 1-7"

Kód UT WoS článku

000377777200025

EID výsledku v databázi Scopus

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