Aggressive extraocular sebaceous carcinoma of the scalp involving the brain in a patient with Muir-Torre syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105593" target="_blank" >RIV/00843989:_____/16:E0105593 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10316662 RIV/61988987:17110/16:A20020XG

Výsledek na webu

<a href="http://dx.doi.org/10.1097/DAD.0000000000000524" target="_blank" >http://dx.doi.org/10.1097/DAD.0000000000000524</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/DAD.0000000000000524" target="_blank" >10.1097/DAD.0000000000000524</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Aggressive extraocular sebaceous carcinoma of the scalp involving the brain in a patient with Muir-Torre syndrome

Popis výsledku v původním jazyce

This article reports an unusual case of aggressive extraocular sebaceous carcinoma located on the scalp with subsequent usurpation of the bone and penetrating through the bone and meninges to the brain in a 56-year-old man affected by Muir-Torre syndrome. Microscopically, the sebaceous neoplasm was located in the middle to deep dermis without any connection to the epidermis and showed a multinodular growth with neoplastic nodules with a central comedo-type necrosis separated from each other by fibrovascular stroma. The nodules were composed of varying proportions of mature sebaceous cells and atypical basaloid cells with high degree of atypia, including high nuclear/cytoplasmic ratio, nuclear pleomorphism, macronucleoli, atypical mitoses, and necrosis. The neoplasm was totally removed. Histopathological examinations of the recurrent lesion showed identical morphological features and, in addition, signs of the tumors growing through the periosteum were noted. In the final excision specimen, both the dura mater and the brain tissue were infiltrated by the sebaceous carcinoma. The diagnosis of Muir-Torre syndrome was confirmed by molecular genetic investigation that revealed an identical germline mutation in MSH2 gene in several family members, some of whom had colorectal tumors.

Název v anglickém jazyce

Aggressive extraocular sebaceous carcinoma of the scalp involving the brain in a patient with Muir-Torre syndrome

Popis výsledku anglicky

This article reports an unusual case of aggressive extraocular sebaceous carcinoma located on the scalp with subsequent usurpation of the bone and penetrating through the bone and meninges to the brain in a 56-year-old man affected by Muir-Torre syndrome. Microscopically, the sebaceous neoplasm was located in the middle to deep dermis without any connection to the epidermis and showed a multinodular growth with neoplastic nodules with a central comedo-type necrosis separated from each other by fibrovascular stroma. The nodules were composed of varying proportions of mature sebaceous cells and atypical basaloid cells with high degree of atypia, including high nuclear/cytoplasmic ratio, nuclear pleomorphism, macronucleoli, atypical mitoses, and necrosis. The neoplasm was totally removed. Histopathological examinations of the recurrent lesion showed identical morphological features and, in addition, signs of the tumors growing through the periosteum were noted. In the final excision specimen, both the dura mater and the brain tissue were infiltrated by the sebaceous carcinoma. The diagnosis of Muir-Torre syndrome was confirmed by molecular genetic investigation that revealed an identical germline mutation in MSH2 gene in several family members, some of whom had colorectal tumors.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Dermatopathology

ISSN

0193-1091

e-ISSN

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Svazek periodika

38

Číslo periodika v rámci svazku

n. 8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

"p. 618-622"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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