Biobanking - the first step to successful liquid biopsy experiments
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106558" target="_blank" >RIV/00843989:_____/17:E0106558 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/17:00097853 RIV/65269705:_____/17:00067233
Výsledek na webu
<a href="http://dx.doi.org/10.14735/amko20172S9" target="_blank" >http://dx.doi.org/10.14735/amko20172S9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amko20172S9" target="_blank" >10.14735/amko20172S9</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biobanking - the first step to successful liquid biopsy experiments
Popis výsledku v původním jazyce
Background: Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.
Název v anglickém jazyce
Biobanking - the first step to successful liquid biopsy experiments
Popis výsledku anglicky
Background: Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
30204 - Oncology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Klinická onkologie
ISSN
0862-495X
e-ISSN
1802-5307
Svazek periodika
30
Číslo periodika v rámci svazku
suppl.2
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
1
Strana od-do
2s9-2s12
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-85029468163