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Biobanking - the first step to successful liquid biopsy experiments

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106558" target="_blank" >RIV/00843989:_____/17:E0106558 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216224:14110/17:00097853 RIV/65269705:_____/17:00067233

  • Výsledek na webu

    <a href="http://dx.doi.org/10.14735/amko20172S9" target="_blank" >http://dx.doi.org/10.14735/amko20172S9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14735/amko20172S9" target="_blank" >10.14735/amko20172S9</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Biobanking - the first step to successful liquid biopsy experiments

  • Popis výsledku v původním jazyce

    Background: Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.

  • Název v anglickém jazyce

    Biobanking - the first step to successful liquid biopsy experiments

  • Popis výsledku anglicky

    Background: Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.

Klasifikace

  • Druh

    J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS

  • CEP obor

  • OECD FORD obor

    30204 - Oncology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Klinická onkologie

  • ISSN

    0862-495X

  • e-ISSN

    1802-5307

  • Svazek periodika

    30

  • Číslo periodika v rámci svazku

    suppl.2

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    1

  • Strana od-do

    2s9-2s12

  • Kód UT WoS článku

  • EID výsledku v databázi Scopus

    2-s2.0-85029468163