Serum cytokine and growth factor levels in children with autism spectrum disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107059" target="_blank" >RIV/00843989:_____/18:E0107059 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.medscimonit.com/abstract/index/idArt/906817" target="_blank" >https://www.medscimonit.com/abstract/index/idArt/906817</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.906817" target="_blank" >10.12659/MSM.906817</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum cytokine and growth factor levels in children with autism spectrum disorder

Popis výsledku v původním jazyce

Background: The immune system may have a role in the pathogenesis of autism spectrum disorder (ASD), including typical and atypical autism. The aim of this study was to determine whether a cytokine and growth factor panel could be identified for the diagnosis and prognosis in children with ASD, including typical and atypical autism. Material/Methods: This study included 26 children with ASD (typical or atypical) and 11 of their siblings who did not have ASD. A panel often serum cytokines and growth factors were investigated using addressable laser bead assay (ALBIA) and enzyme-linked immunosorbent assay (ELISA) kits. Results were correlated with scores using the Childhood Autism Rating Scale (CARS) and Autism Diagnostic Observation Schedule (ADOS) for the children with ASD and compared with the findings from their siblings without ASD. Results: There were no statistically significant differences in serum cytokine and growth factor levels between children with ASD and their siblings. The scores using CARS and ADOS were significantly greater in children with typical autism compared with children with atypical autism as part of the ASD spectrum. Serum levels of cytokines and growth factors showed a positive correlation with CARS and ADOS scores but differed between children with typical and atypical autism and their siblings. Conclusions: The findings of this study showed that serum measurement of appropriately selected panels of cytokines and growth factors might have a role in the diagnosis of ASD.

Název v anglickém jazyce

Serum cytokine and growth factor levels in children with autism spectrum disorder

Popis výsledku anglicky

Background: The immune system may have a role in the pathogenesis of autism spectrum disorder (ASD), including typical and atypical autism. The aim of this study was to determine whether a cytokine and growth factor panel could be identified for the diagnosis and prognosis in children with ASD, including typical and atypical autism. Material/Methods: This study included 26 children with ASD (typical or atypical) and 11 of their siblings who did not have ASD. A panel often serum cytokines and growth factors were investigated using addressable laser bead assay (ALBIA) and enzyme-linked immunosorbent assay (ELISA) kits. Results were correlated with scores using the Childhood Autism Rating Scale (CARS) and Autism Diagnostic Observation Schedule (ADOS) for the children with ASD and compared with the findings from their siblings without ASD. Results: There were no statistically significant differences in serum cytokine and growth factor levels between children with ASD and their siblings. The scores using CARS and ADOS were significantly greater in children with typical autism compared with children with atypical autism as part of the ASD spectrum. Serum levels of cytokines and growth factors showed a positive correlation with CARS and ADOS scores but differed between children with typical and atypical autism and their siblings. Conclusions: The findings of this study showed that serum measurement of appropriately selected panels of cytokines and growth factors might have a role in the diagnosis of ASD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical science monitor

ISSN

1234-1010

e-ISSN

1643-3750

Svazek periodika

24

Číslo periodika v rámci svazku

april

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

2639-2646

Kód UT WoS článku

000431079700001

EID výsledku v databázi Scopus

2-s2.0-85046637977