Calprotectin and calgranulin C serum levels in bacterial sepsis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F19%3AE0107726" target="_blank" >RIV/00843989:_____/19:E0107726 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10396531 RIV/61383082:_____/19:00000496

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0732889318304802?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0732889318304802?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.006" target="_blank" >10.1016/j.diagmicrobio.2018.10.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Calprotectin and calgranulin C serum levels in bacterial sepsis

Popis výsledku v původním jazyce

The aim of this study was to evaluate the serum levels of calprotectin and calgranulin C and routine biomarkers in patients with bacterial sepsis (BS). The initial serum concentrations of calprotectin and calgranulin C were significantly higher in patients with BS (n = 66) than in those with viral infections (n = 24) and the healthy controls (n = 26); the level of calprotectin was found to be the best predictor of BS, followed by the neutrophil-lymphocyte count ratio (NLCR) and the level of procalcitonin (PCT). The white blood cell (WBC) count and the NLCR rapidly returned to normal levels, whereas PCT levels normalized later and the increased levels of calprotectin, calgranulin C, and C-reactive protein persisted until the end of follow-up. Our results suggest that the serum levels of calprotectin are a reliable biomarker of BS and that the WBC count and the NLCR are rapid predictors of the efficacy of antimicrobial therapy. (C) 2018 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Calprotectin and calgranulin C serum levels in bacterial sepsis

Popis výsledku anglicky

The aim of this study was to evaluate the serum levels of calprotectin and calgranulin C and routine biomarkers in patients with bacterial sepsis (BS). The initial serum concentrations of calprotectin and calgranulin C were significantly higher in patients with BS (n = 66) than in those with viral infections (n = 24) and the healthy controls (n = 26); the level of calprotectin was found to be the best predictor of BS, followed by the neutrophil-lymphocyte count ratio (NLCR) and the level of procalcitonin (PCT). The white blood cell (WBC) count and the NLCR rapidly returned to normal levels, whereas PCT levels normalized later and the increased levels of calprotectin, calgranulin C, and C-reactive protein persisted until the end of follow-up. Our results suggest that the serum levels of calprotectin are a reliable biomarker of BS and that the WBC count and the NLCR are rapid predictors of the efficacy of antimicrobial therapy. (C) 2018 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/NV15-30186A" target="_blank" >NV15-30186A: Alarminy v rozvoji a diagnostice septických komplikací tkáňového poškození</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diagnostic microbiology and infectious disease

ISSN

0732-8893

e-ISSN

1879-0070

Svazek periodika

93

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

219-226

Kód UT WoS článku

000460196900008

EID výsledku v databázi Scopus

2-s2.0-85056432107