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Comparison of DOS and Windows version of the MwPharm - a pharmacokinetic software for PK/PD monitoring of digoxin

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F20%3AE0108671" target="_blank" >RIV/00843989:_____/20:E0108671 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://www.klinickafarmakologie.cz/pdfs/far/2020/04/01.pdf" target="_blank" >https://www.klinickafarmakologie.cz/pdfs/far/2020/04/01.pdf</a>

  • DOI - Digital Object Identifier

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Comparison of DOS and Windows version of the MwPharm - a pharmacokinetic software for PK/PD monitoring of digoxin

  • Popis výsledku v původním jazyce

    Background and objectives: Digoxin is the oldest drug indicated for the treatment of systolic heart failure (HF). It is also useful in controlling excessive ventricular rate in the presence of atrial arrhythmias. Therapeutic drug monitoring (TDM) has become an integral part of its prescription, allowing to optimize therapy and to reduce the incidence of toxicity. Since 1991, the MwPharm software package (Mediware, Groningen, The Netherlands / Prague, Czech Republic) has been used for pharmacokinetic and pharmacodynamic (PK/PD) modelling in TDM, including digoxin. First Windows version with a broader spectrum was released in 2014, as a reaction of worse support of the DOS background on later versions of Windows. After its release, the company had decided to not develop DOS versions anymore, even though they are globally used with success. The aim of this study was to compare the usefulness of DOS and Windows version (WIN) of the MwPharm, and their prediction quality in TDM of digoxin. Materials and methods: 29 patients (23 with multidrug treated systolic HF, 4 with atrial fibrillation, 1 pregnant woman treated due to fetus tachycardia, 1 infant with Tetralogy of Fallot) who were treated for > 1 month with digoxin were eligible for inclusion. Patients received digoxin (Digoxin Léčiva®?, Zentiva, Prague, Czech Republic) in a median dose 0.125 mg (range 0.063–0.250 mg) once daily. The therapeutic range for digoxin was established at 0.5–2.0 µg/l, according to manufacturer requirements. Both MwPharm versions (DOS version – MwPharm 3.30, Windows version – MwPharm++ 1.3.5) were used to parameterize the po- pulation PK model. Serum digoxin concentrations (SDC) were repeatedly examined and the differences between measured and calculated values predicted by both versions, including the percentage prediction error (%PE), were compared. Results: SDC were obtained from 29 patients (mean age 67±20 years, body weight 72±27 kg). WIN, compared to DOS, used lower constants for abs...

  • Název v anglickém jazyce

    Comparison of DOS and Windows version of the MwPharm - a pharmacokinetic software for PK/PD monitoring of digoxin

  • Popis výsledku anglicky

    Background and objectives: Digoxin is the oldest drug indicated for the treatment of systolic heart failure (HF). It is also useful in controlling excessive ventricular rate in the presence of atrial arrhythmias. Therapeutic drug monitoring (TDM) has become an integral part of its prescription, allowing to optimize therapy and to reduce the incidence of toxicity. Since 1991, the MwPharm software package (Mediware, Groningen, The Netherlands / Prague, Czech Republic) has been used for pharmacokinetic and pharmacodynamic (PK/PD) modelling in TDM, including digoxin. First Windows version with a broader spectrum was released in 2014, as a reaction of worse support of the DOS background on later versions of Windows. After its release, the company had decided to not develop DOS versions anymore, even though they are globally used with success. The aim of this study was to compare the usefulness of DOS and Windows version (WIN) of the MwPharm, and their prediction quality in TDM of digoxin. Materials and methods: 29 patients (23 with multidrug treated systolic HF, 4 with atrial fibrillation, 1 pregnant woman treated due to fetus tachycardia, 1 infant with Tetralogy of Fallot) who were treated for > 1 month with digoxin were eligible for inclusion. Patients received digoxin (Digoxin Léčiva®?, Zentiva, Prague, Czech Republic) in a median dose 0.125 mg (range 0.063–0.250 mg) once daily. The therapeutic range for digoxin was established at 0.5–2.0 µg/l, according to manufacturer requirements. Both MwPharm versions (DOS version – MwPharm 3.30, Windows version – MwPharm++ 1.3.5) were used to parameterize the po- pulation PK model. Serum digoxin concentrations (SDC) were repeatedly examined and the differences between measured and calculated values predicted by both versions, including the percentage prediction error (%PE), were compared. Results: SDC were obtained from 29 patients (mean age 67±20 years, body weight 72±27 kg). WIN, compared to DOS, used lower constants for abs...

Klasifikace

  • Druh

    J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS

  • CEP obor

  • OECD FORD obor

    30104 - Pharmacology and pharmacy

Návaznosti výsledku

  • Projekt

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Klinická farmakologie a farmacie

  • ISSN

    1212-7973

  • e-ISSN

    1803-5353

  • Svazek periodika

    34

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    6

  • Strana od-do

    152-157

  • Kód UT WoS článku

  • EID výsledku v databázi Scopus

    2-s2.0-85101977251