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Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109426" target="_blank" >RIV/00843989:_____/22:E0109426 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/61383082:_____/21:00001073 RIV/61988987:17110/21:A2202CFK RIV/61383082:_____/22:00001183 RIV/00216208:11110/22:10426102 a 5 dalších

  • Výsledek na webu

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/jum.15703" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jum.15703</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/jum.15703" target="_blank" >10.1002/jum.15703</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

  • Popis výsledku v původním jazyce

    Objectives: Transcranial color-coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods: Self-sufficient patients with atherosclerotic plaque causing 20-70% carotid stenosis were consecutively enrolled to the study. All patients underwent duplex sonography of cervical arteries and TCCS with measurement of PI and RI in the middle cerebral artery, neurological, and physical examinations. Following data were recorded: age, gender, height, weight, body mass index, systolic and diastolic blood pressure, occurrence of current and previous diseases, surgery, medication, smoking, and daily dose of alcohol. Univariant and multivariant logistic regression analysis were used for identification of the factors influencing RI and PI. Results: Totally 1863 subjects were enrolled to the study: 139 healthy controls (54 males, age 55.52 ± 7.05 years) in derivation cohort and 1724 patients (777 males, age 68.73 ± 9.39 years) in validation cohort. The cut off value for RI was 0.63 and for PI 1.21. Independent factors for increased RI/PI were age (odds ratio [OR] = 1.108/1.105 per 1 year), occurrence of diabetes mellitus (OR = 1.767/2.170), arterial hypertension (OR = 1.700 for RI only), width of the carotid plaque (OR = 1.260 per 10% stenosis for RI only), and male gender (OR = 1.530 for PI only; P ?.01 in all cases). Conclusions: The independent predictors of increased cerebral arterial resistance and/or pulsatility in patients with carotid atherosclerosis were age, arterial hypertension, diabetes mellitus, carotid plaque width, and male gender.

  • Název v anglickém jazyce

    Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

  • Popis výsledku anglicky

    Objectives: Transcranial color-coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods: Self-sufficient patients with atherosclerotic plaque causing 20-70% carotid stenosis were consecutively enrolled to the study. All patients underwent duplex sonography of cervical arteries and TCCS with measurement of PI and RI in the middle cerebral artery, neurological, and physical examinations. Following data were recorded: age, gender, height, weight, body mass index, systolic and diastolic blood pressure, occurrence of current and previous diseases, surgery, medication, smoking, and daily dose of alcohol. Univariant and multivariant logistic regression analysis were used for identification of the factors influencing RI and PI. Results: Totally 1863 subjects were enrolled to the study: 139 healthy controls (54 males, age 55.52 ± 7.05 years) in derivation cohort and 1724 patients (777 males, age 68.73 ± 9.39 years) in validation cohort. The cut off value for RI was 0.63 and for PI 1.21. Independent factors for increased RI/PI were age (odds ratio [OR] = 1.108/1.105 per 1 year), occurrence of diabetes mellitus (OR = 1.767/2.170), arterial hypertension (OR = 1.700 for RI only), width of the carotid plaque (OR = 1.260 per 10% stenosis for RI only), and male gender (OR = 1.530 for PI only; P ?.01 in all cases). Conclusions: The independent predictors of increased cerebral arterial resistance and/or pulsatility in patients with carotid atherosclerosis were age, arterial hypertension, diabetes mellitus, carotid plaque width, and male gender.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30210 - Clinical neurology

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV17-31016A" target="_blank" >NV17-31016A: Morfologické charakteristiky aterosklerotického plátu v karotické tepně spojené s progresí plátu a rizikem cévní mozkové příhody</a><br>

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2022

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Ultrasound in Medicine

  • ISSN

    0278-4297

  • e-ISSN

    1550-9613

  • Svazek periodika

    41

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    10

  • Strana od-do

    237-246

  • Kód UT WoS článku

    000635685600001

  • EID výsledku v databázi Scopus

    2-s2.0-85103399984