Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109426" target="_blank" >RIV/00843989:_____/22:E0109426 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/21:00001073 RIV/61988987:17110/21:A2202CFK RIV/61383082:_____/22:00001183 RIV/00216208:11110/22:10426102 a 5 dalších

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/jum.15703" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jum.15703</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jum.15703" target="_blank" >10.1002/jum.15703</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

Popis výsledku v původním jazyce

Objectives: Transcranial color-coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods: Self-sufficient patients with atherosclerotic plaque causing 20-70% carotid stenosis were consecutively enrolled to the study. All patients underwent duplex sonography of cervical arteries and TCCS with measurement of PI and RI in the middle cerebral artery, neurological, and physical examinations. Following data were recorded: age, gender, height, weight, body mass index, systolic and diastolic blood pressure, occurrence of current and previous diseases, surgery, medication, smoking, and daily dose of alcohol. Univariant and multivariant logistic regression analysis were used for identification of the factors influencing RI and PI. Results: Totally 1863 subjects were enrolled to the study: 139 healthy controls (54 males, age 55.52 ± 7.05 years) in derivation cohort and 1724 patients (777 males, age 68.73 ± 9.39 years) in validation cohort. The cut off value for RI was 0.63 and for PI 1.21. Independent factors for increased RI/PI were age (odds ratio [OR] = 1.108/1.105 per 1 year), occurrence of diabetes mellitus (OR = 1.767/2.170), arterial hypertension (OR = 1.700 for RI only), width of the carotid plaque (OR = 1.260 per 10% stenosis for RI only), and male gender (OR = 1.530 for PI only; P ?.01 in all cases). Conclusions: The independent predictors of increased cerebral arterial resistance and/or pulsatility in patients with carotid atherosclerosis were age, arterial hypertension, diabetes mellitus, carotid plaque width, and male gender.

Název v anglickém jazyce

Peripheral vascular resistance in cerebral arteries in patients with carotid atherosclerosis - substudy results of the atherosclerotic plaque characteristics associated with a progression rate of the plaque and a risk of stroke in patients with the carotid bifurcation plaque study (ANTIQUE)

Popis výsledku anglicky

Objectives: Transcranial color-coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods: Self-sufficient patients with atherosclerotic plaque causing 20-70% carotid stenosis were consecutively enrolled to the study. All patients underwent duplex sonography of cervical arteries and TCCS with measurement of PI and RI in the middle cerebral artery, neurological, and physical examinations. Following data were recorded: age, gender, height, weight, body mass index, systolic and diastolic blood pressure, occurrence of current and previous diseases, surgery, medication, smoking, and daily dose of alcohol. Univariant and multivariant logistic regression analysis were used for identification of the factors influencing RI and PI. Results: Totally 1863 subjects were enrolled to the study: 139 healthy controls (54 males, age 55.52 ± 7.05 years) in derivation cohort and 1724 patients (777 males, age 68.73 ± 9.39 years) in validation cohort. The cut off value for RI was 0.63 and for PI 1.21. Independent factors for increased RI/PI were age (odds ratio [OR] = 1.108/1.105 per 1 year), occurrence of diabetes mellitus (OR = 1.767/2.170), arterial hypertension (OR = 1.700 for RI only), width of the carotid plaque (OR = 1.260 per 10% stenosis for RI only), and male gender (OR = 1.530 for PI only; P ?.01 in all cases). Conclusions: The independent predictors of increased cerebral arterial resistance and/or pulsatility in patients with carotid atherosclerosis were age, arterial hypertension, diabetes mellitus, carotid plaque width, and male gender.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV17-31016A" target="_blank" >NV17-31016A: Morfologické charakteristiky aterosklerotického plátu v karotické tepně spojené s progresí plátu a rizikem cévní mozkové příhody</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Ultrasound in Medicine

ISSN

0278-4297

e-ISSN

1550-9613

Svazek periodika

41

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

237-246

Kód UT WoS článku

000635685600001

EID výsledku v databázi Scopus

2-s2.0-85103399984