Microbiota diversity in non-small cell lung cancer gut and mouth cavity microbiota diversity in non-small cell lung cancer patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110580" target="_blank" >RIV/00843989:_____/23:E0110580 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/23:A2402NCS RIV/61989100:27350/23:10253509 RIV/61989100:27640/23:10253509 RIV/00098892:_____/23:10158507 RIV/61989592:15110/23:73622108

Výsledek na webu

<a href="https://sciendo.com/article/10.33073/pjm-2023-044" target="_blank" >https://sciendo.com/article/10.33073/pjm-2023-044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33073/pjm-2023-044" target="_blank" >10.33073/pjm-2023-044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microbiota diversity in non-small cell lung cancer gut and mouth cavity microbiota diversity in non-small cell lung cancer patients

Popis výsledku v původním jazyce

Lung malignancies have a substantial impact on cancer incidence and mortality worldwide. Even though many factors involved in the development of the disease are known, many questions remain unanswered. Previous studies suggest that the intestinal microbiota may have a role in developing malignant diseases. According to some findings, the microbiota has proven to be a key modulator of carcinogenic processes and the immune response against cancer cells, potentially influencing the effectiveness of immunotherapy. In our study, we characterized culturable microorganisms associated with non-small cell lung cancer (NSCLC) that can be recovered from rectal swabs and mouthwash. In addition, we also explored differences in the culturable microbiota with two main types of NSCLC - adenocarcinoma (ADC) and squamous cell carcinoma (SCC). With 141 patients included in the study (86 ADC and 55 SCC cases), a significant difference was observed between the two types in seven bacterial species (Collinsella, Corynebacterium, Klebsiella, Lactobacillus, Neisseria, Rothia, and Streptococcus), including the site of origin. The relationship between microbial dysbiosis and lung cancer is poorly understood; future research could shed light on the links between gut microbiota and lung cancer development.

Název v anglickém jazyce

Microbiota diversity in non-small cell lung cancer gut and mouth cavity microbiota diversity in non-small cell lung cancer patients

Popis výsledku anglicky

Lung malignancies have a substantial impact on cancer incidence and mortality worldwide. Even though many factors involved in the development of the disease are known, many questions remain unanswered. Previous studies suggest that the intestinal microbiota may have a role in developing malignant diseases. According to some findings, the microbiota has proven to be a key modulator of carcinogenic processes and the immune response against cancer cells, potentially influencing the effectiveness of immunotherapy. In our study, we characterized culturable microorganisms associated with non-small cell lung cancer (NSCLC) that can be recovered from rectal swabs and mouthwash. In addition, we also explored differences in the culturable microbiota with two main types of NSCLC - adenocarcinoma (ADC) and squamous cell carcinoma (SCC). With 141 patients included in the study (86 ADC and 55 SCC cases), a significant difference was observed between the two types in seven bacterial species (Collinsella, Corynebacterium, Klebsiella, Lactobacillus, Neisseria, Rothia, and Streptococcus), including the site of origin. The relationship between microbial dysbiosis and lung cancer is poorly understood; future research could shed light on the links between gut microbiota and lung cancer development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NV19-03-00069" target="_blank" >NV19-03-00069: Korelace molekulárních biomarkerů potenciálně důležitých pro imunoterapii s kvalitou střevního mikrobiomu u pacientů s NSCLC</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polish journal of microbiology

ISSN

1733-1331

e-ISSN

2544-4646

Svazek periodika

72

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

9

Strana od-do

467-475

Kód UT WoS článku

001126091300002

EID výsledku v databázi Scopus

2-s2.0-85179898716