Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111529" target="_blank" >RIV/00843989:_____/25:E0111529 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/25:A2603AIJ RIV/61989592:15110/25:73628137 RIV/00098892:_____/25:10158842

Výsledek na webu

<a href="https://biomed.papers.upol.cz/artkey/bio-202501-0001_acute-kidney-injury-due-to-gentamicin-nephrotoxicity-and-specific-mirnas-as-biomarkers.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202501-0001_acute-kidney-injury-due-to-gentamicin-nephrotoxicity-and-specific-mirnas-as-biomarkers.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2024.031" target="_blank" >10.5507/bp.2024.031</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers

Popis výsledku v původním jazyce

Acute kidney injury (AKI) due to gentamicin nephrotoxicity is a significant concern in clinical medicine, particularly in patients receiving prolonged or high-dose gentamicin therapy. Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of a range of bacterial infections. However, its use is associated with nephrotoxicity which can manifest as AKI. Due to this, it is crucial to diagnose promptly and manage treatment effectively. Ongoing studies are therefore focusing on non-protein-coding RNAs as potential biomarkers for AKI. Numerous microRNAs (miRNAs) have been implicated in gentamicin-induced nephrotoxicity and AKI. They participate in pathways associated with inflammation, cell death, and oxidative stress and each of these factors play critical roles in the development of gentamicin-induced kidney injury. Research studies have demonstrated changes in the expression levels of these miRNAs in response to gentamicin exposure both in vitro and in in vivo models, as well as in human clinical trials involving patients receiving gentamicin therapy. The dysregulation of these miRNAs correlates with the severity of kidney injury and may serve as sensitive biomarkers for early detection and monitoring of AKI induced by gentamicin.

Název v anglickém jazyce

Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers

Popis výsledku anglicky

Acute kidney injury (AKI) due to gentamicin nephrotoxicity is a significant concern in clinical medicine, particularly in patients receiving prolonged or high-dose gentamicin therapy. Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of a range of bacterial infections. However, its use is associated with nephrotoxicity which can manifest as AKI. Due to this, it is crucial to diagnose promptly and manage treatment effectively. Ongoing studies are therefore focusing on non-protein-coding RNAs as potential biomarkers for AKI. Numerous microRNAs (miRNAs) have been implicated in gentamicin-induced nephrotoxicity and AKI. They participate in pathways associated with inflammation, cell death, and oxidative stress and each of these factors play critical roles in the development of gentamicin-induced kidney injury. Research studies have demonstrated changes in the expression levels of these miRNAs in response to gentamicin exposure both in vitro and in in vivo models, as well as in human clinical trials involving patients receiving gentamicin therapy. The dysregulation of these miRNAs correlates with the severity of kidney injury and may serve as sensitive biomarkers for early detection and monitoring of AKI induced by gentamicin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical papers

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

169

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

001334882700001

EID výsledku v databázi Scopus

2-s2.0-86000714883