The mechanism of action of neuromodulation in the treatment of overactive bladder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111802" target="_blank" >RIV/00843989:_____/25:E0111802 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/25:A2603DQ4

Výsledek na webu

<a href="https://doi.org/10.1038/s41585-024-00967-8" target="_blank" >https://doi.org/10.1038/s41585-024-00967-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41585-024-00967-8" target="_blank" >10.1038/s41585-024-00967-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The mechanism of action of neuromodulation in the treatment of overactive bladder

Popis výsledku v původním jazyce

Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.

Název v anglickém jazyce

The mechanism of action of neuromodulation in the treatment of overactive bladder

Popis výsledku anglicky

Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature reviews urology

ISSN

1759-4812

e-ISSN

1759-4820

Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

414-426

Kód UT WoS článku

001372723400001

EID výsledku v databázi Scopus

2-s2.0-85211905329