Association of residual shunts after PFO closure with recurrent stroke risk: Single-center experience

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0112057" target="_blank" >RIV/00843989:_____/25:E0112057 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143525 RIV/61988987:17110/25:A2603DD8 RIV/61989592:15310/25:73633953 RIV/61989100:27240/25:10259613

Výsledek na webu

<a href="https://journals.viamedica.pl/polish_heart_journal/article/view/108057/84327" target="_blank" >https://journals.viamedica.pl/polish_heart_journal/article/view/108057/84327</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33963/v.phj.108057" target="_blank" >10.33963/v.phj.108057</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of residual shunts after PFO closure with recurrent stroke risk: Single-center experience

Popis výsledku v původním jazyce

Background: Literature on residual right-to-left shunts after patent foramen ovale (PFO) closure shows conflicting results regarding stroke recurrence risk, although recent data suggest increased risk with moderate and large residual shunts. Aims: To evaluate the effect of the presence and grade of residual shunt on the risk of stroke/transient ischemic attack (TIA) after PFO closure. Material and methods: We retrospectively analyzed data from a prospectively maintained registry of 498 patients who underwent PFO closure following cryptogenic stroke/TIA between 2004 and 2022. Residual shunts (RS) were classified as grade 0 (none), grade I (<10 microbubbles), grade II (10-20), or grade III (>20) using transesophageal echocardiography and transcranial Doppler at 6 and 12 months. Recurrent ischemic events during 7-year follow-up (mean 5.24 ± 2.0 years) were assessed via medical records. Risk ratios with 95% confidence intervals adjusted for follow-up duration were calculated. Results: In the study population (median age 52 years), RS was present in 35% of patients at 6 months, decreasing to 19% at 12 months (grade II or III: 13%). The annual risk of TIA/stroke was significantly higher in patients with any RS compared to those without (risk ratio [RR], 3.57; 95% confidence interval [CI], 1.52-8.43), particularly driven by grade III shunts (RR, 3.71; 95% CI, 1.21-11.39). Conclusions: Although the incidence of residual shunting decreases over time, residual right-to-left shunting following PFO closure is associated with a significantly increased risk of recurrent ischemic stroke or TIA.

Název v anglickém jazyce

Association of residual shunts after PFO closure with recurrent stroke risk: Single-center experience

Popis výsledku anglicky

Background: Literature on residual right-to-left shunts after patent foramen ovale (PFO) closure shows conflicting results regarding stroke recurrence risk, although recent data suggest increased risk with moderate and large residual shunts. Aims: To evaluate the effect of the presence and grade of residual shunt on the risk of stroke/transient ischemic attack (TIA) after PFO closure. Material and methods: We retrospectively analyzed data from a prospectively maintained registry of 498 patients who underwent PFO closure following cryptogenic stroke/TIA between 2004 and 2022. Residual shunts (RS) were classified as grade 0 (none), grade I (<10 microbubbles), grade II (10-20), or grade III (>20) using transesophageal echocardiography and transcranial Doppler at 6 and 12 months. Recurrent ischemic events during 7-year follow-up (mean 5.24 ± 2.0 years) were assessed via medical records. Risk ratios with 95% confidence intervals adjusted for follow-up duration were calculated. Results: In the study population (median age 52 years), RS was present in 35% of patients at 6 months, decreasing to 19% at 12 months (grade II or III: 13%). The annual risk of TIA/stroke was significantly higher in patients with any RS compared to those without (risk ratio [RR], 3.57; 95% confidence interval [CI], 1.52-8.43), particularly driven by grade III shunts (RR, 3.71; 95% CI, 1.21-11.39). Conclusions: Although the incidence of residual shunting decreases over time, residual right-to-left shunting following PFO closure is associated with a significantly increased risk of recurrent ischemic stroke or TIA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Kardiologia Polska

ISSN

0022-9032

e-ISSN

1897-4279

Svazek periodika

83

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

8

Strana od-do

1268-1275

Kód UT WoS článku

001636244200001

EID výsledku v databázi Scopus

2-s2.0-105024259730