Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F16556267%3A_____%2F12%3A%230000134" target="_blank" >RIV/16556267:_____/12:#0000134 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/12:00372907 RIV/00216208:11130/12:8916 RIV/00216208:11120/12:43901029 RIV/00064211:_____/12:#0000175

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Influence%20of%20immunization%20with%20non-genotoxic%20PAH-KLH%20conjugates%20on%20the%20resistance%20of%20organisms%20exposed%20to%20benzo(a)pyrene" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed?term=Influence%20of%20immunization%20with%20non-genotoxic%20PAH-KLH%20conjugates%20on%20the%20resistance%20of%20organisms%20exposed%20to%20benzo(a)pyrene</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene.

Popis výsledku v původním jazyce

Polycyclic aromatic hydrocarbons (PAH) are recognized as common environmental pollutants released into the environment from many natural as well as man-made sources, and some have been classified as potent carcinogens. The main representative of the carcinogenic PAH is benzo(a)pyrene (B(a)P) which is known to induce genotoxic effects in vitro and in vivo, detected as PAH-DNA adducts. Long-term PAH exposure may be accompanied by an immunological response with the formation of antibodies against PAH as well as against PAH-DNA adducts. This paper describes the use of four PAH-keyhole-limpet haemocyanin (KLH) conjugates for the induction of specific and cross-reactive anti-PAH antibodies and focuses on the potential protective effects of anti-PAH antibodies produced after immunization of mice. In the in vitro experiments with HepG-2 cells, the genotoxicity of the PAH-KLH conjugates and the neutralizing effect of induced anti-PAH antibodies were evaluated. The titer of specific anti-PAH ant

Název v anglickém jazyce

Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene.

Popis výsledku anglicky

Polycyclic aromatic hydrocarbons (PAH) are recognized as common environmental pollutants released into the environment from many natural as well as man-made sources, and some have been classified as potent carcinogens. The main representative of the carcinogenic PAH is benzo(a)pyrene (B(a)P) which is known to induce genotoxic effects in vitro and in vivo, detected as PAH-DNA adducts. Long-term PAH exposure may be accompanied by an immunological response with the formation of antibodies against PAH as well as against PAH-DNA adducts. This paper describes the use of four PAH-keyhole-limpet haemocyanin (KLH) conjugates for the induction of specific and cross-reactive anti-PAH antibodies and focuses on the potential protective effects of anti-PAH antibodies produced after immunization of mice. In the in vitro experiments with HepG-2 cells, the genotoxicity of the PAH-KLH conjugates and the neutralizing effect of induced anti-PAH antibodies were evaluated. The titer of specific anti-PAH ant

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

<a href="/cs/project/2B06150" target="_blank" >2B06150: Modulace hladiny protilátek proti polycyklickým aromatickým uhlovodíkům (PAU) ve vztahu ke kouření, nádorovému a nenádorovému onemocnění plic a výzkum možnosti zvyšování odolnosti organismu vůči působení PAU imunizací.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

ISSN

1383-5718

e-ISSN

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Svazek periodika

Volume 742

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

2-10

Kód UT WoS článku

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EID výsledku v databázi Scopus

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