The role of ventricular remodeling in the early decompensation of cardiorenal syndrome: Insight from studies with Ren-2 transgenic hypertensive rats subjected to volume overload induced using aorto-caval fistula

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26068877%3A_____%2F25%3AN0000038" target="_blank" >RIV/26068877:_____/25:N0000038 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41440-025-02440-4" target="_blank" >https://www.nature.com/articles/s41440-025-02440-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41440-025-02440-4" target="_blank" >10.1038/s41440-025-02440-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of ventricular remodeling in the early decompensation of cardiorenal syndrome: Insight from studies with Ren-2 transgenic hypertensive rats subjected to volume overload induced using aorto-caval fistula

Popis výsledku v původním jazyce

The aim of the present study was to evaluate the role of the left ventricle (LV) remodeling in the process of the transition from the compensation to the decompensation phase of cardiorenal syndrome. Ren-2 transgenic rats (TGR) with aorto-caval fistula (ACF) were used as the model of cardiorenal syndrome. Two weeks after ACF creation or sham operation, heart morphological parameters, cardiac structure and function were assessed by echocardiography and invasive pressure-volume analysis. This time point was chosen because two weeks after ACF the TGR still exhibit 100% survival rate and are in the transition phase from the compensation to the decompensation of cardiorenal syndrome. Our results at this stage show: (i) ACF TGR have already fully developed eccentric LV hypertrophy as compared with sham-operated TGR which exhibited signs of LV concentric hypertrophy; (ii) the increase in whole heart weight in ACF TGR was dominantly mediated by right ventricle (RV) hypertrophy, whereas the increase in the LV mass was minimal; (iii) ACF TGR displayed, besides bilateral ventricular dilatation, significant impairment of LV systolic functions whereas RV systolic functions were not impaired as compared with sham-operated TGR. Based on our present results, we propose that the inability of the LV to develop an appropriate hypertrophic response leads to maladaptive ventricular remodeling, which is likely a crucial factor in the process of the transition from the compensation to the decompensation phase of cardiorenal syndrome.

Název v anglickém jazyce

The role of ventricular remodeling in the early decompensation of cardiorenal syndrome: Insight from studies with Ren-2 transgenic hypertensive rats subjected to volume overload induced using aorto-caval fistula

Popis výsledku anglicky

The aim of the present study was to evaluate the role of the left ventricle (LV) remodeling in the process of the transition from the compensation to the decompensation phase of cardiorenal syndrome. Ren-2 transgenic rats (TGR) with aorto-caval fistula (ACF) were used as the model of cardiorenal syndrome. Two weeks after ACF creation or sham operation, heart morphological parameters, cardiac structure and function were assessed by echocardiography and invasive pressure-volume analysis. This time point was chosen because two weeks after ACF the TGR still exhibit 100% survival rate and are in the transition phase from the compensation to the decompensation of cardiorenal syndrome. Our results at this stage show: (i) ACF TGR have already fully developed eccentric LV hypertrophy as compared with sham-operated TGR which exhibited signs of LV concentric hypertrophy; (ii) the increase in whole heart weight in ACF TGR was dominantly mediated by right ventricle (RV) hypertrophy, whereas the increase in the LV mass was minimal; (iii) ACF TGR displayed, besides bilateral ventricular dilatation, significant impairment of LV systolic functions whereas RV systolic functions were not impaired as compared with sham-operated TGR. Based on our present results, we propose that the inability of the LV to develop an appropriate hypertrophic response leads to maladaptive ventricular remodeling, which is likely a crucial factor in the process of the transition from the compensation to the decompensation phase of cardiorenal syndrome.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hypertension Research

ISSN

0916-9636

e-ISSN

1348-4214

Svazek periodika

49

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

24

Strana od-do

777-800

Kód UT WoS článku

001610573000001

EID výsledku v databázi Scopus

2-s2.0-105021436082