Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F15%3A%230000211" target="_blank" >RIV/26475821:_____/15:#0000211 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors

Popis výsledku v původním jazyce

Poster describing Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors. Patients with advanced stages of malignant tumors often have elevated levels of circulating free DNA (cell-free DNA, cfDNA) in peripheral blood. cfDNA is released as a result of apoptosis and necrosis processes, both directly from the mass of the tumor and from surrounding non-tumor tissue. In terms of diagnostic and therapeutic procedure, especially tumor cfDNA component is important from overall cfDNA amount. Its presence can facilitate acquisition of DNA material for tumor molecular profiling to diagnosis and prediction of patients response to biological targeted therapies.All this without the implementation of frequent invasive and costly investigations. In this work we present utility of ctDNA for the determination of tumor phenotype within the basic division into the mutator phenotype (microsatellite instability, MSI and chromosomal instability, CIN) or methylator phe

Název v anglickém jazyce

Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors

Popis výsledku anglicky

Poster describing Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors. Patients with advanced stages of malignant tumors often have elevated levels of circulating free DNA (cell-free DNA, cfDNA) in peripheral blood. cfDNA is released as a result of apoptosis and necrosis processes, both directly from the mass of the tumor and from surrounding non-tumor tissue. In terms of diagnostic and therapeutic procedure, especially tumor cfDNA component is important from overall cfDNA amount. Its presence can facilitate acquisition of DNA material for tumor molecular profiling to diagnosis and prediction of patients response to biological targeted therapies.All this without the implementation of frequent invasive and costly investigations. In this work we present utility of ctDNA for the determination of tumor phenotype within the basic division into the mutator phenotype (microsatellite instability, MSI and chromosomal instability, CIN) or methylator phe

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14383" target="_blank" >NT14383: Využití volné nádorové DNA jako nového cíle pro minimálně-invazivní diagnostiku a zpřesnění molekulární klasifikace kolorektálních nádorů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů