Prospective longitudinal molecular characterization of colorectal tumors based on CIMP/MSI/BRAF/KRAS classification: comparison of advanced adenomas to early and late carcinomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F16%3AN0000026" target="_blank" >RIV/26475821:_____/16:N0000026 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prospective longitudinal molecular characterization of colorectal tumors based on CIMP/MSI/BRAF/KRAS classification: comparison of advanced adenomas to early and late carcinomas

Popis výsledku v původním jazyce

Poster at DDW 2016: There is a growing evidence that molecular subtypes defined by of CpG-island mutator phenotype (CIMP) and BRAF mutation combined with presence or absence of microsatellite instability (MSI) and KRAS mutation indicate prognosis of colorectal cancer patients (1,2,3). In this project, we have performed molecular testing of tissue specimens acquired during colonoscopy. The main goal was to compare molecular profiles at proximal, distal and rectal tumor localizations and to assess overall feasibility and clinical utility for prognosis assesment in future clinical practice. Prospective molecular classification of tissue specimens for assesment of patients prognosis is feasible in routine endoscopy practice. Increase in CIMP, BRAF and MSI positive sample rates with the developmental stages of colorectal tumors correspond to fundamental molecular processes accompanying cancer initiation and progression and overall differences in prognosis. As expected, a clear distinction is notable for tumors located in proximal colon supposedly arising from the serrated (methylation) pathway. The increasing rates of TP53 mutations confirm its role as a late event in tumor development.

Název v anglickém jazyce

Prospective longitudinal molecular characterization of colorectal tumors based on CIMP/MSI/BRAF/KRAS classification: comparison of advanced adenomas to early and late carcinomas

Popis výsledku anglicky

Poster at DDW 2016: There is a growing evidence that molecular subtypes defined by of CpG-island mutator phenotype (CIMP) and BRAF mutation combined with presence or absence of microsatellite instability (MSI) and KRAS mutation indicate prognosis of colorectal cancer patients (1,2,3). In this project, we have performed molecular testing of tissue specimens acquired during colonoscopy. The main goal was to compare molecular profiles at proximal, distal and rectal tumor localizations and to assess overall feasibility and clinical utility for prognosis assesment in future clinical practice. Prospective molecular classification of tissue specimens for assesment of patients prognosis is feasible in routine endoscopy practice. Increase in CIMP, BRAF and MSI positive sample rates with the developmental stages of colorectal tumors correspond to fundamental molecular processes accompanying cancer initiation and progression and overall differences in prognosis. As expected, a clear distinction is notable for tumors located in proximal colon supposedly arising from the serrated (methylation) pathway. The increasing rates of TP53 mutations confirm its role as a late event in tumor development.

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14383" target="_blank" >NT14383: Využití volné nádorové DNA jako nového cíle pro minimálně-invazivní diagnostiku a zpřesnění molekulární klasifikace kolorektálních nádorů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů