Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid haemorrhage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005366" target="_blank" >RIV/27283933:_____/17:00005366 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.23736/S0390-5616.16.03411" target="_blank" >http://dx.doi.org/10.23736/S0390-5616.16.03411</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0390-5616.16.03411" target="_blank" >10.23736/S0390-5616.16.03411</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid haemorrhage

Popis výsledku v původním jazyce

BACKGROUND: Dysnatremias are common and carry a risk of poor prognosis in acute subarachnoid hemorrhage (SAH) patients. The aim of this study was to determine the frequency and outcome of dysnatremias in 344 SAH patients treated by a targeted sodium management regimen. METHODS: We performed a 10-year observational dysnatremia study. Hyponatremia was defined as serum sodium (SNa) below 135 mmol/L, hypernatremia SNa above 150 mmol/L. RESULTS: Dysnatremia occurred in 35.8% patients; this was more frequently hyponatremia (19.8%) with a mean SNa 132.23±2.09 mmol/L, (16.0% mild, 3.2% moderate, 0.6% severe). Hypernatremia occurred less commonly in 11.9%, P<0.001 with a mean SNa 154.21±3.72 mmol/L, (6.1% mild, 2.9% moderate, 2.9% severe). In 4.8% of patients there were episodes of both dysnatremias. The incidence of hypo-osmolar hyponatremia was 6.4%, Cerebral salt wasting (CSW) 3.5%, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 0.3% and Central diabetes insipidus 1.7%. The hypernatremic patients had a higher inpatient mortality rate (P=0.001) and a worse overall outcome (P<0.001) than those hyponatremic or normotremic patients. Multivariate logistic regression showed that hypernatremia was an independent risk factor for increased inpatient mortality and poor outcome in patients with SAH. CONCLUSIONS: Our 10-year targeted sodium management regimen in acute SAH patients showed that dysnatremias were frequent, predominantly hyponatremia of which the more usual causes were CSW and not SIADH. Hypernatremia was shown to be an independent risk factor for inpatient mortality and poor outcome.

Název v anglickém jazyce

Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid haemorrhage

Popis výsledku anglicky

BACKGROUND: Dysnatremias are common and carry a risk of poor prognosis in acute subarachnoid hemorrhage (SAH) patients. The aim of this study was to determine the frequency and outcome of dysnatremias in 344 SAH patients treated by a targeted sodium management regimen. METHODS: We performed a 10-year observational dysnatremia study. Hyponatremia was defined as serum sodium (SNa) below 135 mmol/L, hypernatremia SNa above 150 mmol/L. RESULTS: Dysnatremia occurred in 35.8% patients; this was more frequently hyponatremia (19.8%) with a mean SNa 132.23±2.09 mmol/L, (16.0% mild, 3.2% moderate, 0.6% severe). Hypernatremia occurred less commonly in 11.9%, P<0.001 with a mean SNa 154.21±3.72 mmol/L, (6.1% mild, 2.9% moderate, 2.9% severe). In 4.8% of patients there were episodes of both dysnatremias. The incidence of hypo-osmolar hyponatremia was 6.4%, Cerebral salt wasting (CSW) 3.5%, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 0.3% and Central diabetes insipidus 1.7%. The hypernatremic patients had a higher inpatient mortality rate (P=0.001) and a worse overall outcome (P<0.001) than those hyponatremic or normotremic patients. Multivariate logistic regression showed that hypernatremia was an independent risk factor for increased inpatient mortality and poor outcome in patients with SAH. CONCLUSIONS: Our 10-year targeted sodium management regimen in acute SAH patients showed that dysnatremias were frequent, predominantly hyponatremia of which the more usual causes were CSW and not SIADH. Hypernatremia was shown to be an independent risk factor for inpatient mortality and poor outcome.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurosurgical Sciences

ISSN

0390-5616

e-ISSN

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Svazek periodika

—

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

9

Strana od-do

371-379

Kód UT WoS článku

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EID výsledku v databázi Scopus

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