Poster Abstracts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005389" target="_blank" >RIV/27283933:_____/17:00005389 - isvavai.cz</a>

Výsledek na webu

<a href="https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417" target="_blank" >https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tme.12417" target="_blank" >10.1111/tme.12417</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Poster Abstracts

Popis výsledku v původním jazyce

Therapeutic plasma exchange (TPE) is a therapeuticoption in a variety of diseases. In most indications, albumin is recommended as a replacement fluid. During TPE coagulation factors areremoved and a depletion of coagulation factors results. We have found norecommendations for the assessment of haemostasis and managementof bleeding risk in patients undergoing TPE. The increased bleeding riskis important in the management of these patients. The only published data about assessment of haemostasis by rotational thromboelastome-try (ROTEM) in patients after TPE are in patients using TPE beforecadaveric donor kidney transplant.1WefoundnodataofROTEMusein patients, where TPE protocols with series of TPE were used. We have performed rotational thromboelastometry in patients with Guillain-Barré syndrome undergoing TPE therapy. All patients had a series of TPE, the interval between TPE was 24–48 hours.Albumin was used as a replacement fluid. We performed standard coagulation tests and rotational thromboelastometry before and after each TPE. TPE reduced fibrinogen levels both in a standard laboratorytest and according to FIBTEM (MCF). Clotting time (CT) and clot formation time (CFT) were prolonged both in INTEM and EXTEM. Standard coagulation tests were also prolonged (aPTT, INR). Thromboelastometry results reflected a serious coagulopathy. The coagulopathybetween each TPE in most cases corrected spontaneously, but in somecases the coagulopathy and especially the reduced fibrinogen level prevailed even after 48 hours and haemostasis did not normalise betweeneach TPE session. Haemostasis is severely influenced by TPE with albumin. The resulting coagulopathy should be assessed individually in eachpatient. The bleeding risk should be monitored and measured beforeeach invasive procedure and the timing of invasive procedures (centralvein cannulation, tracheostomy or spinal tap) should be individualisedaccording to results. It should be taken into consideration that in somepatients the coagulopathy prevails throughout the series of TPE and corrects spontaneously only after the TPE series is over. Rotational thromboelastometry can be used to assess haemostasis and bleeding risk inthese patients.

Název v anglickém jazyce

Poster Abstracts

Popis výsledku anglicky

Therapeutic plasma exchange (TPE) is a therapeuticoption in a variety of diseases. In most indications, albumin is recommended as a replacement fluid. During TPE coagulation factors areremoved and a depletion of coagulation factors results. We have found norecommendations for the assessment of haemostasis and managementof bleeding risk in patients undergoing TPE. The increased bleeding riskis important in the management of these patients. The only published data about assessment of haemostasis by rotational thromboelastome-try (ROTEM) in patients after TPE are in patients using TPE beforecadaveric donor kidney transplant.1WefoundnodataofROTEMusein patients, where TPE protocols with series of TPE were used. We have performed rotational thromboelastometry in patients with Guillain-Barré syndrome undergoing TPE therapy. All patients had a series of TPE, the interval between TPE was 24–48 hours.Albumin was used as a replacement fluid. We performed standard coagulation tests and rotational thromboelastometry before and after each TPE. TPE reduced fibrinogen levels both in a standard laboratorytest and according to FIBTEM (MCF). Clotting time (CT) and clot formation time (CFT) were prolonged both in INTEM and EXTEM. Standard coagulation tests were also prolonged (aPTT, INR). Thromboelastometry results reflected a serious coagulopathy. The coagulopathybetween each TPE in most cases corrected spontaneously, but in somecases the coagulopathy and especially the reduced fibrinogen level prevailed even after 48 hours and haemostasis did not normalise betweeneach TPE session. Haemostasis is severely influenced by TPE with albumin. The resulting coagulopathy should be assessed individually in eachpatient. The bleeding risk should be monitored and measured beforeeach invasive procedure and the timing of invasive procedures (centralvein cannulation, tracheostomy or spinal tap) should be individualisedaccording to results. It should be taken into consideration that in somepatients the coagulopathy prevails throughout the series of TPE and corrects spontaneously only after the TPE series is over. Rotational thromboelastometry can be used to assess haemostasis and bleeding risk inthese patients.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Transfusion Medicine

ISBN

—

ISSN

0958-7578

e-ISSN

—

Počet stran výsledku

2

Strana od-do

22-71

Název nakladatele

Wiley

Místo vydání

Oxford

Místo konání akce

Florencie

Datum konání akce

1. 1. 2017

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—