Safety And Efficacy of Routine Endovascular Thrombectomy in Acute Occlusive Stroke Recorded in the International Sits Thrombectomy Register - an Observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F18%3A00005510" target="_blank" >RIV/27283933:_____/18:00005510 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.sagepub.com/doi/pdf/10.1177/2396987318770127" target="_blank" >http://journals.sagepub.com/doi/pdf/10.1177/2396987318770127</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/2396987318770127" target="_blank" >10.1177/2396987318770127</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Safety And Efficacy of Routine Endovascular Thrombectomy in Acute Occlusive Stroke Recorded in the International Sits Thrombectomy Register - an Observational study

Popis výsledku v původním jazyce

Background and Aims: Endovascular thrombectomy (EVT) significantly improved functional outcomes among patients with anterior circulation acute ischemic stroke (ACIS) due to evaluate the safety and efficacy of EVT in ACIS recorded in the SITS International Thrombectomy Register (TBYR) and compared to patients in the EVT arms of pooled randomized controlled trials (RCTs). Method: We identified centres recording>=10 consecutive patients in the SITS-TBYR with at least 70% of available modified Rankin Scyle (mRS) at 3-months during 2014 to 2017. We analysed LAO as intracranial ICA, MI, M2, AI, A2 treated with thrombectomy with of without prior IVT given within 4,5 hours of stroke onset. Primary efficacy outcome was functional independence (mRS score 0-2) at 3 months and safety outcomes were symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST (any haemorrhagic transformation on 22-36 h imaging scans and worsening of > = 4p on NIHSS within 24 h and death within 3 months. Results: In total. 2780 (89% with available 3 month outcomes) patients from 24 centres were treated with thrombectomy: 1751 (63%) with prior IVT, 1029 (37%) without. Median age was 72 (61-80), vs. 68 (57-77) years; baseline NIHSS score was 17 (12-21) vs. 17 (14-20) in SITS-EVT vs. RCTs. Functional independence at 3 months was 45,9% (95% CI: 43.9-47,9), vs. 46,0% 42,0-50,0) and death 18,2% (16,7-19,7) vs. 15,3% (12,7-18,4), SICH 4,8%(4,1-5,7) vs. 4,4% (3,0-6,4) in SITS-EVT vs. RCTs. Conclusion: Our results demonstrated that thrombectomy is safe and effective in routine clinical use in ACIS with LAO.

Název v anglickém jazyce

Safety And Efficacy of Routine Endovascular Thrombectomy in Acute Occlusive Stroke Recorded in the International Sits Thrombectomy Register - an Observational study

Popis výsledku anglicky

Background and Aims: Endovascular thrombectomy (EVT) significantly improved functional outcomes among patients with anterior circulation acute ischemic stroke (ACIS) due to evaluate the safety and efficacy of EVT in ACIS recorded in the SITS International Thrombectomy Register (TBYR) and compared to patients in the EVT arms of pooled randomized controlled trials (RCTs). Method: We identified centres recording>=10 consecutive patients in the SITS-TBYR with at least 70% of available modified Rankin Scyle (mRS) at 3-months during 2014 to 2017. We analysed LAO as intracranial ICA, MI, M2, AI, A2 treated with thrombectomy with of without prior IVT given within 4,5 hours of stroke onset. Primary efficacy outcome was functional independence (mRS score 0-2) at 3 months and safety outcomes were symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST (any haemorrhagic transformation on 22-36 h imaging scans and worsening of > = 4p on NIHSS within 24 h and death within 3 months. Results: In total. 2780 (89% with available 3 month outcomes) patients from 24 centres were treated with thrombectomy: 1751 (63%) with prior IVT, 1029 (37%) without. Median age was 72 (61-80), vs. 68 (57-77) years; baseline NIHSS score was 17 (12-21) vs. 17 (14-20) in SITS-EVT vs. RCTs. Functional independence at 3 months was 45,9% (95% CI: 43.9-47,9), vs. 46,0% 42,0-50,0) and death 18,2% (16,7-19,7) vs. 15,3% (12,7-18,4), SICH 4,8%(4,1-5,7) vs. 4,4% (3,0-6,4) in SITS-EVT vs. RCTs. Conclusion: Our results demonstrated that thrombectomy is safe and effective in routine clinical use in ACIS with LAO.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů