Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F18%3A00006514" target="_blank" >RIV/27283933:_____/18:00006514 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop

Popis výsledku v původním jazyce

Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop after the delivery with a part of patients non-reacting to usual therapy. These patients may suffer from PTMS – postpartum thrombotic microangiopathic syndrome. Its symptoms remind of HELLP syndrome by its laboratory parameters and clinical signs, these however do not respond to classic therapy and even progressively deteriorate. The Hemolytic-uraemic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP), Systemic lupus erythematosus (SLE) and Antiphospholipide syndrome (APS) are some of the diseases included. On the basis of microangiopathy the disseminated intravascular coagulation and multiorgan failure may develop and repeated Postpartum plasma exchange (PPEX) is often necessary.

Název v anglickém jazyce

Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop

Popis výsledku anglicky

Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop after the delivery with a part of patients non-reacting to usual therapy. These patients may suffer from PTMS – postpartum thrombotic microangiopathic syndrome. Its symptoms remind of HELLP syndrome by its laboratory parameters and clinical signs, these however do not respond to classic therapy and even progressively deteriorate. The Hemolytic-uraemic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP), Systemic lupus erythematosus (SLE) and Antiphospholipide syndrome (APS) are some of the diseases included. On the basis of microangiopathy the disseminated intravascular coagulation and multiorgan failure may develop and repeated Postpartum plasma exchange (PPEX) is often necessary.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů