Cystic and alveolar echinococcosis: Zoonotic infections with different Epidemiology and clinical Course

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cystic and alveolar echinococcosis: Zoonotic infections with different Epidemiology and clinical Course

Popis výsledku v původním jazyce

Human echinococcosis is caused by larval stages of several Echinococcus species, small intestinal flatworms of canines. Two most important species are E. granulosus causing cystic echinococcosis (CE) with nearly worldwide distribution, and E. multilocularis causing alveolar echinococcosis (AE), an emerging infection in the western, central and eastern Europe. The human diseases are rare in the Czech Republic (CZ). CE is relatively benign, however, AE is potentially life-threatening due to progressive tumor-like growth in liver and risk of metastatic dissemination. There have been treated total 12 patients (4 women, 8 men) with CE since 2005, and 13 patients (9 women, 4 men) with AE since 2012 at our departments. CE seems not to be more endemic in the CZ. Ten CE cases were diagnosed in migrants from endemic regions: Bulgaria (3x), Romania, Macedonia, Montenegro, Russia, Kazakhstan, Tajikistan, and Uzbekistan. Two patients are Czech citizens: a 68-year old female acquired infection in the CZ in past, probably, a 36-year old man is living in the CZ, but he travelled to eastern Europe and Asia for many times. The age of CE patients was between 28 and 68 years at the time of diagnosis. 10 patients had cysts in liver only, 1 patient in lung only and 1 patient in both liver and lung. Serology for echinococcosis was positive in all patients. The treatment involved surgery and temporary albendazole in 10 patients, temporary albendazole only in 1 patient and “wait and watch” in 1 patient. All AE cases were acquired in the CZ (12 patients) or in Slovakia (1 patient). The age of AE patients was between 7 and 70 years at the time of diagnosis. 12 patients had lesions in liver only, 1 patient had the main mass in liver and multiple metastasis in lung. Serology for echinococcosis was borderline or positive at all patients. The treatment is based on longterm continuous albendazole administration, which is not tolerated in 1 patient (treated with mebendazole). In addition, 7 patients underwent liver resection, 2 patients liver transplantation and one patient died from AE unrelated reason.

Název v anglickém jazyce

Cystic and alveolar echinococcosis: Zoonotic infections with different Epidemiology and clinical Course

Popis výsledku anglicky

Human echinococcosis is caused by larval stages of several Echinococcus species, small intestinal flatworms of canines. Two most important species are E. granulosus causing cystic echinococcosis (CE) with nearly worldwide distribution, and E. multilocularis causing alveolar echinococcosis (AE), an emerging infection in the western, central and eastern Europe. The human diseases are rare in the Czech Republic (CZ). CE is relatively benign, however, AE is potentially life-threatening due to progressive tumor-like growth in liver and risk of metastatic dissemination. There have been treated total 12 patients (4 women, 8 men) with CE since 2005, and 13 patients (9 women, 4 men) with AE since 2012 at our departments. CE seems not to be more endemic in the CZ. Ten CE cases were diagnosed in migrants from endemic regions: Bulgaria (3x), Romania, Macedonia, Montenegro, Russia, Kazakhstan, Tajikistan, and Uzbekistan. Two patients are Czech citizens: a 68-year old female acquired infection in the CZ in past, probably, a 36-year old man is living in the CZ, but he travelled to eastern Europe and Asia for many times. The age of CE patients was between 28 and 68 years at the time of diagnosis. 10 patients had cysts in liver only, 1 patient in lung only and 1 patient in both liver and lung. Serology for echinococcosis was positive in all patients. The treatment involved surgery and temporary albendazole in 10 patients, temporary albendazole only in 1 patient and “wait and watch” in 1 patient. All AE cases were acquired in the CZ (12 patients) or in Slovakia (1 patient). The age of AE patients was between 7 and 70 years at the time of diagnosis. 12 patients had lesions in liver only, 1 patient had the main mass in liver and multiple metastasis in lung. Serology for echinococcosis was borderline or positive at all patients. The treatment is based on longterm continuous albendazole administration, which is not tolerated in 1 patient (treated with mebendazole). In addition, 7 patients underwent liver resection, 2 patients liver transplantation and one patient died from AE unrelated reason.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30303 - Infectious Diseases

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů