Negativní prognostický význam primární řasinky, CD8 tumor infiltrujících lymfocytů a PD1 exprese u renálního karcinomu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F19%3A00006947" target="_blank" >RIV/27283933:_____/19:00006947 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Negativní prognostický význam primární řasinky, CD8 tumor infiltrujících lymfocytů a PD1 exprese u renálního karcinomu

Popis výsledku v původním jazyce

Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8 tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8 TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1 cells were 50% in 5 patients. Intratumoral CD8 TIL were evaluable in all patients: negative in 1 patient, 50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (≥0.002) than in patients with lower frequency (25%) PD1 expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1 cells and CD8 TIL in patients with clear cell renal cancer.

Název v anglickém jazyce

Negative prognostic significance of primary cilia, CD8 tumor infiltrating lymphocytes and PD1 cells expression in clear cell renal cancer

Popis výsledku anglicky

Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8 tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8 TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1 cells were 50% in 5 patients. Intratumoral CD8 TIL were evaluable in all patients: negative in 1 patient, 50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (≥0.002) than in patients with lower frequency (25%) PD1 expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1 cells and CD8 TIL in patients with clear cell renal cancer.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů