Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low Grade Neoplasms: A Case with a Highly Increased Proliferation Rate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F24%3AN0000014" target="_blank" >RIV/27283933:_____/24:N0000014 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/24:00084917

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/38403790/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38403790/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12022-024-09802-7" target="_blank" >10.1007/s12022-024-09802-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low Grade Neoplasms: A Case with a Highly Increased Proliferation Rate

Popis výsledku v původním jazyce

Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classifed as pancreatic neuroendocrine microtumors in the 2022 WHO classifcation of endocrine and neuroendocrine tumors. This case report discussed the features of an incidentally identifed 4.7-mm glucagon-expressing pancreatic neuroendocrine microtumor with MEN1 mutation only, chromosomally stable and an epigenetic alpha-like phenotype. The tumor was associated with an unexplained increased proliferation rate in Ki-67 of 15%. There was no associated DAXX/ATRX defciency. The presented case challenges the conventional thought of a low proliferative disease of the so-called “pancreatic neuroendocrine microadenomas” and provides additional support to the 2022 WHO classifcation that also requires grading of these neoplasms. Despite exhibiting molecular features of less aggressive behavior, the case also underscores the biological complexity of pancreatic neuroendocrine microtumors. By recognizing the heterogenous spectrum of neuroendocrine neoplasms, the current case also contributes to ongoing discussions on how to optimize the clinical management of such tumors.

Název v anglickém jazyce

Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low Grade Neoplasms: A Case with a Highly Increased Proliferation Rate

Popis výsledku anglicky

Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classifed as pancreatic neuroendocrine microtumors in the 2022 WHO classifcation of endocrine and neuroendocrine tumors. This case report discussed the features of an incidentally identifed 4.7-mm glucagon-expressing pancreatic neuroendocrine microtumor with MEN1 mutation only, chromosomally stable and an epigenetic alpha-like phenotype. The tumor was associated with an unexplained increased proliferation rate in Ki-67 of 15%. There was no associated DAXX/ATRX defciency. The presented case challenges the conventional thought of a low proliferative disease of the so-called “pancreatic neuroendocrine microadenomas” and provides additional support to the 2022 WHO classifcation that also requires grading of these neoplasms. Despite exhibiting molecular features of less aggressive behavior, the case also underscores the biological complexity of pancreatic neuroendocrine microtumors. By recognizing the heterogenous spectrum of neuroendocrine neoplasms, the current case also contributes to ongoing discussions on how to optimize the clinical management of such tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Pathology

ISSN

1046-3976

e-ISSN

1559-0097

Svazek periodika

35

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

147-153

Kód UT WoS článku

001170279400001

EID výsledku v databázi Scopus

2-s2.0-85185972541