Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F15%3AN0000018" target="_blank" >RIV/27661989:_____/15:N0000018 - isvavai.cz</a>

Výsledek na webu

<a href="https://publications.ersnet.org/content/erj/46/suppl59/oa2925" target="_blank" >https://publications.ersnet.org/content/erj/46/suppl59/oa2925</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2015.OA2925" target="_blank" >10.1183/13993003.congress-2015.OA2925</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD

Popis výsledku v původním jazyce

Background: The COPD has been recognized as a multiple-faced syndrome. Heterogeneity features of severe COPD patients still remains unknown. Aim: Systematic observation of the variety of symptoms and other clinical characteristics of severe airflow limitation subjects. Methods: The Czech Multicentre Research Database of COPD (Database) is a multicenter, observational, and prospective study of patients with post bronchodilator FEV1≤60%(NCT01923051). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Baseline data includes parameters used for identification of clinical phenotypes. Results: We have enrolled 488 patients from Aug13 to Dec14, 343 of them with complete set of parameters for phenotype assessment (250males,67.0 years,FEV143.0%,6.7% non-smokers). We found all GOLD categories (A 4.4%,B 14.9%,C 3.8%,D 73.8%) and six COPD phenotypes (bronchitic-b 75.5%,emphysematous-e 77.4%,exacerbators-ex 34.7%,bronchiectatic-be 28.4%,cachectic-ca 16.3%,ACOS-ac 4.2%) in our severe COPD cohort. Clinical assessment of phenotypes (without computer tomography) have high sensitivity (0.69-0.74) in majority of them (except be) and excellent specificity in all (0.71-0.99). Some phenotypes are significantly associated with more symptoms (fatigue in b,ex and dyspnea in ex,ca) greater value of BODE index (e,ex,ca), higher values of specific CAT items (b,ca,ex). Contrary e,ac,be COPD have not any CAT items predominance. Conclusion: 1st analysis of baseline data of the Database has confirmed the wide clinical distribution of COPD syndrome. Subjective evaluation by physicians achieves satisfactory sensitivity and specificity.

Název v anglickém jazyce

Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD

Popis výsledku anglicky

Background: The COPD has been recognized as a multiple-faced syndrome. Heterogeneity features of severe COPD patients still remains unknown. Aim: Systematic observation of the variety of symptoms and other clinical characteristics of severe airflow limitation subjects. Methods: The Czech Multicentre Research Database of COPD (Database) is a multicenter, observational, and prospective study of patients with post bronchodilator FEV1≤60%(NCT01923051). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Baseline data includes parameters used for identification of clinical phenotypes. Results: We have enrolled 488 patients from Aug13 to Dec14, 343 of them with complete set of parameters for phenotype assessment (250males,67.0 years,FEV143.0%,6.7% non-smokers). We found all GOLD categories (A 4.4%,B 14.9%,C 3.8%,D 73.8%) and six COPD phenotypes (bronchitic-b 75.5%,emphysematous-e 77.4%,exacerbators-ex 34.7%,bronchiectatic-be 28.4%,cachectic-ca 16.3%,ACOS-ac 4.2%) in our severe COPD cohort. Clinical assessment of phenotypes (without computer tomography) have high sensitivity (0.69-0.74) in majority of them (except be) and excellent specificity in all (0.71-0.99). Some phenotypes are significantly associated with more symptoms (fatigue in b,ex and dyspnea in ex,ca) greater value of BODE index (e,ex,ca), higher values of specific CAT items (b,ca,ex). Contrary e,ac,be COPD have not any CAT items predominance. Conclusion: 1st analysis of baseline data of the Database has confirmed the wide clinical distribution of COPD syndrome. Subjective evaluation by physicians achieves satisfactory sensitivity and specificity.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Svazek periodika

46

Číslo periodika v rámci svazku

Supplement 59

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

1

Strana od-do

Meeting Abstract OA2925

Kód UT WoS článku

000451979400209

EID výsledku v databázi Scopus

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