Nutrition status and comorbidities in patients with severe COPD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F18%3AN0000021" target="_blank" >RIV/27661989:_____/18:N0000021 - isvavai.cz</a>

Výsledek na webu

<a href="https://publications.ersnet.org/content/erj/52/suppl62/pa710" target="_blank" >https://publications.ersnet.org/content/erj/52/suppl62/pa710</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2018.PA710" target="_blank" >10.1183/13993003.congress-2018.PA710</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nutrition status and comorbidities in patients with severe COPD

Popis výsledku v původním jazyce

Aim: To assess comorbidities in patients with severe COPD according to nutrition status. Methods: We analysed baseline data of patients from The Czech National Registry of Severe COPD. Nutrition status (BMI, FFMI), comorbidities and their impact to mortality and other parameters were analysed. Results: A total of 343 patients were included into the analysis,253 men, mean age 66.6 years, mean FEV1 44.9%, average CAT 16.8. There were 10.2% patients with cachexia, 6.4% with underweight, 30.9% patients were obese. Total of 20.7% had muscle mass loss. There were significant differences of nutritional status according to COPD phenotypes, but not in GOLD groups. Patients with underweight had higher CAT (p=0.06), lower FEV1 (p=0.022), lower FEV1/VCmax (p<0.001) and lower TLCO (p<0.001) at baseline than obese patients, but there were no differences among the groups in declination of lung functions during 24 month follow up. Obesity was associated with higher frequency of diabetes mellitus (55%), heart failure (50%) and other cardiovascular disease. Overweight was associated with more comorbidities (about 30%), cachexia with osteoporosis (p=0.006) and depression. Other nutritional groups were associated with lower frequency of comorbidities. There were significant differences in mortality among nutritional groups. The highest mortality in 48 month follow up was in underweight patient and the lowest in overweight group (p<0.001). Conclusion: Poor nutrition is associated with certain COPD phenotypes, worse lung function, more symptoms and higher mortality. We found also differences in frequency of comorbidities in patients with severe COPD acoording to nutrition status that can affect its mortality and supports heterogenity COPD.

Název v anglickém jazyce

Nutrition status and comorbidities in patients with severe COPD

Popis výsledku anglicky

Aim: To assess comorbidities in patients with severe COPD according to nutrition status. Methods: We analysed baseline data of patients from The Czech National Registry of Severe COPD. Nutrition status (BMI, FFMI), comorbidities and their impact to mortality and other parameters were analysed. Results: A total of 343 patients were included into the analysis,253 men, mean age 66.6 years, mean FEV1 44.9%, average CAT 16.8. There were 10.2% patients with cachexia, 6.4% with underweight, 30.9% patients were obese. Total of 20.7% had muscle mass loss. There were significant differences of nutritional status according to COPD phenotypes, but not in GOLD groups. Patients with underweight had higher CAT (p=0.06), lower FEV1 (p=0.022), lower FEV1/VCmax (p<0.001) and lower TLCO (p<0.001) at baseline than obese patients, but there were no differences among the groups in declination of lung functions during 24 month follow up. Obesity was associated with higher frequency of diabetes mellitus (55%), heart failure (50%) and other cardiovascular disease. Overweight was associated with more comorbidities (about 30%), cachexia with osteoporosis (p=0.006) and depression. Other nutritional groups were associated with lower frequency of comorbidities. There were significant differences in mortality among nutritional groups. The highest mortality in 48 month follow up was in underweight patient and the lowest in overweight group (p<0.001). Conclusion: Poor nutrition is associated with certain COPD phenotypes, worse lung function, more symptoms and higher mortality. We found also differences in frequency of comorbidities in patients with severe COPD acoording to nutrition status that can affect its mortality and supports heterogenity COPD.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Svazek periodika

52

Číslo periodika v rámci svazku

Supplement 62

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

PA710

Kód UT WoS článku

000455567107391

EID výsledku v databázi Scopus

—