Furosemide-associated hyponatremia in internal medicine patients: Analysis of epidemiological and biochemical profiles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F23%3A10003382" target="_blank" >RIV/27661989:_____/23:10003382 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0953620523001450" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0953620523001450</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejim.2023.04.033" target="_blank" >10.1016/j.ejim.2023.04.033</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Furosemide-associated hyponatremia in internal medicine patients: Analysis of epidemiological and biochemical profiles

Popis výsledku v původním jazyce

This retrospective study evaluates epidemiological, biochemical and clinical characteristics of patients hospitalized with hypotonic hyponatremia who were treated with furosemide. A total of 504 patients were included, of whom 81 (16.1%) were receiving furosemide. These patients demonstrated higher in‑hospital mortality and markedly impaired renal function parameters, along with increased fractional excretion of sodium, potassium, chloride, and water. However, their biochemical profile did not correspond to the typical pattern of diuretic‑induced hyponatremia. A minority of patients treated with furosemide alone exhibited features of true hypovolemic hyponatremia, suggesting that furosemide may contribute to its development in selected cases. The study highlights the complexity of interpreting electrolyte disturbances in multimorbid patients frequently receiving combined diuretic therapy.

Název v anglickém jazyce

Furosemide-associated hyponatremia in internal medicine patients: Analysis of epidemiological and biochemical profiles

Popis výsledku anglicky

This retrospective study evaluates epidemiological, biochemical and clinical characteristics of patients hospitalized with hypotonic hyponatremia who were treated with furosemide. A total of 504 patients were included, of whom 81 (16.1%) were receiving furosemide. These patients demonstrated higher in‑hospital mortality and markedly impaired renal function parameters, along with increased fractional excretion of sodium, potassium, chloride, and water. However, their biochemical profile did not correspond to the typical pattern of diuretic‑induced hyponatremia. A minority of patients treated with furosemide alone exhibited features of true hypovolemic hyponatremia, suggesting that furosemide may contribute to its development in selected cases. The study highlights the complexity of interpreting electrolyte disturbances in multimorbid patients frequently receiving combined diuretic therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Internal Medicine

ISSN

0953-6205

e-ISSN

1879-0828

Svazek periodika

114

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

3

Strana od-do

138-140

Kód UT WoS článku

001052406300001

EID výsledku v databázi Scopus

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